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Eigenserum und alternative Blutprodukte zur Behandlung von Augenoberflächenerkrankungen

Autologous serum and alternative blood products for the treatment of ocular surface disorders

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Zusammenfassung

Zur Therapie von Erkrankungen der Augenoberfläche wie persistierenden Epitheldefekten und trockenem Auge haben sich in den letzten zehn Jahren Augentropfen aus Eigenserum bewährt. Als Benetzungsmittel mit biologisch aktiven Inhaltsstoffen wie Wachstumsfaktoren, Vitaminen und Nährstoffen eignen sie sich besonders, um die Wundheilungsvorgänge des Hornhautepithels zu unterstützen. Ihre Abgabe zur ambulanten Behandlung darf nach dem Arzneimittelgesetz (AMG) jedoch nur bei Vorlage einer durch die Landesbehörden zu erteilenden Herstellungserlaubnis erfolgen. Diese liegt bislang nur an wenigen Institutionen vor. In dieser Übersicht werden neben den aktuellen Erfahrungen und einem Standardprotokoll zur Herstellung von Eigenserum-Augentropfen der Kenntnisstand zur Verwendung alternativer Blutprodukte in der Therapie von Augenoberflächenstörungen dargestellt und die Vor- und Nachteile der verschiedenen Ansätze diskutiert.

Abstract

Eye drops made from autologous serum have been increasingly used in the past decade to treat ocular surface disorders such as persistent epithelial defects and dry eye. Due to biologically active ingredients such as growth factors, vitamins, and nutrients, they can be used to lubricate the ocular surface and support epithelial wound healing. According to current legal requirements, they can be dispensed only for outpatient treatment if the producer has obtained a license from the appropriate local authorities. Therefore, the production and dispensing of autologous serum eye drops in Germany is currently limited to a very few institutions and their patients. We review the current evidence on the use of serum eye drops, recommend a standard protocol for their production, and describe a number of recently emerging alternative blood products for the treatment of ocular surface diseases along with their potential advantages and limitations.

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Authors and Affiliations

  1. Klinik für Augenheilkunde, Julius-Maximilians-Universität Würzburg, Josef-Schneider-Straße 11, 97080, Würzburg, Deutschland

    G. Geerling, J.D. Unterlauft & K. Kasper

  2. Institut für Transfusionsmedizin, Julius-Maximilians-Universität, Würzburg, Deutschland

    A. Opitz

  3. Augenklinik, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland

    S. Schrader

  4. Institut für Klinische Chemie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland

    D. Hartwig

Authors
  1. G. Geerling
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  2. J.D. Unterlauft
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  3. K. Kasper
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  4. S. Schrader
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  5. A. Opitz
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  6. D. Hartwig
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Correspondence to G. Geerling.

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Der Vortrag wurde in Teilen auf der 105. Tagung der Deutschen Ophthalmologischen Gesellschaft, Berlin, gehalten.

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Geerling, G., Unterlauft, J., Kasper, K. et al. Eigenserum und alternative Blutprodukte zur Behandlung von Augenoberflächenerkrankungen. Ophthalmologe 105, 623–631 (2008). https://doi.org/10.1007/s00347-008-1750-y

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