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Osmoprotektion als therapeutisches Prinzip

Osmoprotection as a new therapeutic principle

  • Das therapeutische Prinzip
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Zusammenfassung

Das Trockene Auge ist eine der häufigsten Erkrankungen in der täglichen ophthalmologischen Praxis. In den letzten Jahren wurde eine Vielzahl neuer Erkenntnisse zur Pathogenese der Erkrankung gewonnen. Die Hyperosmolarität des Tränenfilms beim Trockenen Auge wird für die Entwicklung einer – häufig subklinischen – Entzündung der Augenoberfläche, der Tränendrüse und des Tränenfilms mitverantwortlich gemacht. Osmoprotektiva können mit Hilfe von kompatiblen Soluten die Oberflächenschädigung durch einen hyperosmolaren Tränenfilm theoretisch vermeiden.

Abstract

Dry eye syndrome is one of the most common disorders encountered in daily ophthalmological practice. New pathophysiological concepts have been developed over the last few years. Hyperosmolarity of the tear film is one of the key pathogenetic factors in the development of a – commonly subclinical – inflammation of the ocular surface, the lacrimal gland and the tear film in dry eye syndrome. Osmoprotective agents act through compatible solutes to prevent – at least in theory –a hyperosmolar tear film from damaging the ocular surface.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung/en hin: Beratungs- und Referententätigkeit für Fa. Allergan.

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  1. Augenklinik, Ludwig-Maximilians-Universität, Mathildenstraße 8, 80336, München, Deutschland

    E.M. Messmer

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Messmer, E. Osmoprotektion als therapeutisches Prinzip. Ophthalmologe 104, 987–990 (2007). https://doi.org/10.1007/s00347-007-1649-z

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  • DOI: https://doi.org/10.1007/s00347-007-1649-z

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