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Vitamin D and prostate cancer prognosis: a Mendelian randomization study

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World Journal of Urology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 21 August 2015

Abstract

Purpose

Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.25-OH2) vitamin D levels.

Methods

To examine the hypothesized inverse relationship between vitamin D status and prostate cancer, we studied the association between this SNP and prostate cancer outcome in the prospective PROCAGENE study comprising 702 prostate cancer patients with a median follow-up of 82 months.

Results

GC rs2282679 genotypes were not associated with biochemical recurrence [hazard ratios (HR) 0.91, 95 % confidence interval (CI) 0.73–1.12; p = 0.36], development of metastases (HR 1.20, 95 % CI 0.88–1.63; p = 0.25) or overall survival (HR 1.10; 95 % CI 0.84–1.43; p = 0.50).

Conclusions

A causal role of vitamin D status, as reflected by GC rs2282679 genotype, in disease progression and mortality in prostate cancer patients is unlikely.

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Acknowledgments

This work was supported by BioPersMed (COMET K-Project 825329), which is funded by the Federal Ministry of Transport, Innovation and Technology (BMVIT) and the Federal Ministry of Economics and Labour/the Federal Ministry of Economy, Family and Youth (BMWA/BMWFJ) and the Styrian Business Promotion Agency (SFG). This study was also supported by the Anniversary Fund of the Österreichische Nationalbank, Grant No. 11686.

Authors contribution

O. Trummer: Protocol/project development, Data collection or management, Data analysis, Manuscript writing/editing. U. Langsenlehner: Data collection or management. S. Krenn-Pilko: Data collection or management. T.R. Pieber: Protocol/project development. B. Obermayer-Pietsch: Protocol/project development, Manuscript writing/editing. A. Gerger: Protocol/project development, Manuscript writing/editing. W. Renner: Protocol/project development, Data collection or management, Data analysis, Manuscript writing/editing. T. Langsenlehner: Protocol/project development, Data collection or management, Manuscript writing/editing.

Author information

Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria

    Olivia Trummer, Thomas R. Pieber & Barbara Obermayer-Pietsch

  2. Division of Internal Medicine, GKK Outpatient Department, Graz, Austria

    Uwe Langsenlehner

  3. Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria

    Sabine Krenn-Pilko & Tanja Langsenlehner

  4. Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

    Armin Gerger

  5. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036, Graz, Austria

    Wilfried Renner

Authors
  1. Olivia Trummer
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  2. Uwe Langsenlehner
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  3. Sabine Krenn-Pilko
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  5. Barbara Obermayer-Pietsch
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  8. Tanja Langsenlehner
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Corresponding author

Correspondence to Wilfried Renner.

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The authors declare that they have no conflict of interest.

Ethical standards

The study has been approved by the Ethical Committee of the Medical University of Graz and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Written informed consent was obtained from all participating subjects.

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Trummer, O., Langsenlehner, U., Krenn-Pilko, S. et al. Vitamin D and prostate cancer prognosis: a Mendelian randomization study. World J Urol 34, 607–611 (2016). https://doi.org/10.1007/s00345-015-1646-9

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  • DOI: https://doi.org/10.1007/s00345-015-1646-9

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