Abstract
Purpose
To verify the reliability of HistoScanning™-based, true targeting (TT)-derived prostate biopsy.
Methods
We relied on 40 patients suspicious for prostate cancer who underwent standard and TT-derived prostate biopsy. Sensitivity, specificity, positive predictive value, negative predictive value and the area under the curve (AUC) were assessed for the prediction of biopsy results per octant by HistoScanning™, using different HistoScanning™ signal volume cutoffs (>0, >0.2 and >0.5 ml).
Results
Overall, 319 octants were analyzed. Of those, 64 (20.1 %) harbored prostate cancer. According to different HistoScanning™ signal volume cutoffs (>0, >0.2 and >0.5 ml), the AUCs for predicting biopsy results were: 0.51, 0.51 and 0.53, respectively. Similarly, the sensitivity, specificity, positive predictive and negative predictive values were: 20.7, 78.2, 17.4 and 81.6 %; 20.7, 82.0, 20.3 and 82.3 %; and 12.1, 94.6, 33.3 and 82.9 %, respectively.
Conclusions
Prediction of biopsy results based on HistoScanning™ signals and TT-derived biopsies was unreliable. Moreover, the AUC of TT-derived biopsies was low and did not improve when additional signal volume cutoffs were applied (>0.2 and >0.5 ml). We cannot recommend a variation of well-established biopsy standards or reduction in biopsy cores based on HistoScanning™ signals.
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Jonas Schiffmann and Gisa Mehring have contributed equally to this work.
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Schiffmann, J., Mehring, G., Tennstedt, P. et al. True targeting-derived prostate biopsy: HistoScanning™ remained inadequate despite advanced technical efforts. World J Urol 34, 495–500 (2016). https://doi.org/10.1007/s00345-015-1637-x
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DOI: https://doi.org/10.1007/s00345-015-1637-x