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En bloc transurethral resection with 2-micron continuous-wave laser for primary non-muscle-invasive bladder cancer: a randomized controlled trial

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An Erratum to this article was published on 16 July 2014

Abstract

Purpose

To evaluate the practicability of en bloc transurethral resection with 2-micron continuous-wave laser as treatment for primary non-muscle-invasive bladder cancer (NMIBC).

Methods

This was a single-center, randomized, controlled trial involving 142 patients with newly diagnosed NMIBC. All patients were randomly assigned in a 1:1 ratio to receive either laser treatment or conventional transurethral resection of bladder tumor (TURBT). All patients received intravesical chemotherapy. Follow-up was performed in 18 months. Primary outcome measure was difference of tumor recurrence rate at the end of study.

Results

Baseline characteristics did not differ between patients in two groups. Operation time was longer in laser group than in TURBT group (56.5 ± 37.4 vs. 41.0 ± 29.4 min, P = 0.017). Obturator nerve reflection was noted during TURBT in 18 patients, whereas none was noted during laser resection. Number of T1 tumors was higher in the laser group (25 vs. 15, P = 0.047). According to Kaplan–Meier survival curves, there was no statistical difference in the rate of recurrence in 18 months (P = 0.383). All recurrences were out of the site of first resection, and there was no progression in tumor grade.

Conclusion

Two-micron continuous-wave laser did not diminish tumor recurrence rate in primary NMIBC for 18-months observation. However, T1 tumors were significantly higher among laser group. Clear and complete tumor bases were easily conserved by laser resection, which may enable pathologists to distinguish the T stages of bladder cancer more easily. Further studies need to be done in future.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical standards

Ethical approval was obtained from the Ethics Committee of the Medical Faculty of the First Affiliated Hospital, Sun Yat-Sen University. Clinical data were obtained with the written consent of the patients.

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Authors and Affiliations

  1. Department of Urology, Sun Yat-Sen University, Guangzhou, China

    Xu Chen, Jun Liao, Lingwu Chen, Shaopeng Qiu, Chengqiang Mo, Xiaopeng Mao, Yuanzhong Yang, Shiying Zhou & Junxing Chen

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  1. Xu Chen
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  2. Jun Liao
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  3. Lingwu Chen
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  4. Shaopeng Qiu
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  5. Chengqiang Mo
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  6. Xiaopeng Mao
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  7. Yuanzhong Yang
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  8. Shiying Zhou
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  9. Junxing Chen
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Correspondence to Junxing Chen.

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Chen, X., Liao, J., Chen, L. et al. En bloc transurethral resection with 2-micron continuous-wave laser for primary non-muscle-invasive bladder cancer: a randomized controlled trial. World J Urol 33, 989–995 (2015). https://doi.org/10.1007/s00345-014-1342-1

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  • DOI: https://doi.org/10.1007/s00345-014-1342-1

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