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Efficacy of antibiotic prophylaxis in patients undergoing cystoscopy: a randomized clinical trial

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Abstract

Objective

To establish the efficacy of antibiotic prophylaxis prior to cystoscopy in outpatients in decreasing the incidence of post-procedure urinary tract infection.

Study design and setting

A randomized clinical trial in patients (men and women) older than 18 who underwent cystoscopy for any non-urgent indication. The intervention was Levofloxacin 500 mg single dose, and the control was placebo 500 mg single dose made with similar characteristics. The primary outcome was urinary tract infection (UTI) measured 3–10 days after the procedure. It was performed as per protocol analysis.

Results

Hundred and thirty-eight patients in each study arm completed the trial. The incidence of UTI in the intervention group was 0.7 % and in the placebo group was 3 % (p = 0.17), and no significant differences were found. The incidence of asymptomatic bacteriuria in the intervention group was 5.8 % and in the control group was 14.5 % (p = 0.01).

Conclusions

No significant differences were found in the use of prophylactic antibiotic compared to placebo to reduce the incidence of UTI in patients who undergo cystoscopy as an outpatient procedure with sterile urine demonstrated by urine culture.

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Authors and Affiliations

  1. University of Valle, Cra 35 No 3a-38 Ap 301, Cali, Colombia

    Herney Andrés García-Perdomo, Jorge Carbonell & Diego Castillo

  2. University of Rosario, Bogotá, Argentina

    Hugo López

  3. Javeriana University, Bogotá, Colombia

    Juan Guillermo Cataño

  4. University of the Frontera, Temuco, Chile

    Pamela Serón

Authors
  1. Herney Andrés García-Perdomo
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  2. Hugo López
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  3. Jorge Carbonell
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  4. Diego Castillo
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  5. Juan Guillermo Cataño
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  6. Pamela Serón
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Corresponding author

Correspondence to Herney Andrés García-Perdomo.

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García-Perdomo, H.A., López, H., Carbonell, J. et al. Efficacy of antibiotic prophylaxis in patients undergoing cystoscopy: a randomized clinical trial. World J Urol 31, 1433–1439 (2013). https://doi.org/10.1007/s00345-013-1034-2

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  • DOI: https://doi.org/10.1007/s00345-013-1034-2

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