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Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer

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Abstract

Purpose

Molecular epidemiology studies have shown that vitamin D receptor (VDR) gene polymorphisms are associated with prostate cancer risk. However, the prognostic value of these polymorphisms on clinical outcomes in prostate cancer patients receiving androgen-deprivation therapy (ADT) has not been determined.

Methods

We evaluated the association of five common VDR polymorphisms, ApaI, Tru9I, BsmI, FokI, and Cdx2, with clinicopathologic characteristics and clinical outcomes, including disease progression, prostate cancer-specific mortality, and all-cause mortality, in a cohort of 601 prostate cancer patients treated with ADT.

Results

Of the five VDR polymorphisms, FokI rs2228570 and BsmI rs1544410 were associated with Gleason score at diagnosis (P = 0.043) and prostate-specific antigen nadir following ADT (P = 0.023), respectively. The haplotype analysis revealed that the A–A–G (ApaI-Tru9I-BsmI) compared with C–G–G individuals were more likely to have high Gleason score (P = 0.050). However, none of these polymorphisms were significantly associated with disease progression and mortality after ADT.

Conclusions

This is the largest study to date investigating the association of VDR polymorphisms and clinical outcomes in prostate cancer patients receiving ADT. Polymorphisms in the VDR gene might be associated with Gleason score, but these polymorphisms had no main effect on predicting response to ADT.

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Abbreviations

VDR:

Vitamin D receptor

ADT:

Androgen-deprivation therapy

SNP:

Single nucleotide polymorphism

PCSM:

Prostate cancer-specific mortality

ACM:

All-cause mortality

PSA:

Prostate-specific antigen

HR:

Hazard ratio

CI:

Confidence interval

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Acknowledgments

This work was supported by the National Science Council (NSC), Taiwan (grants NSC-98-2320-B-039-019-MY3, NSC-99-2314-B-037-018-MY3, and NSC-100-2314-B-039-009-MY3), China Medical University (grant CMU99-COL-13), and Kaohsiung Medical University Hospital (grant KMUH99-9R12). We thank the National Center for Genome Medicine, NSC, Taiwan, for technical support.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pharmacy, Yangming Branch, Taipei City Hospital, Taipei, Taiwan

    Jiunn-Bey Pao & Ying-Pi Yang

  2. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Chun-Nung Huang & Shu-Pin Huang

  3. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Shu-Pin Huang

  4. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Shu-Pin Huang

  5. Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

    Tzyh-Chyuan Hour

  6. Department of Occupational Safety and Health, China Medical University, Taichung, Taiwan

    Ta-Yuan Chang

  7. Department of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, 40402, Taiwan

    Yu-Hsuan Lan, Te-Ling Lu, Hong-Zin Lee & Bo-Ying Bao

  8. Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan

    Shin-Hun Juang

  9. Department of Urology, National Taiwan University Hospital, Taipei, Taiwan

    Chao-Yuan Huang

  10. Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan

    Bo-Ying Bao

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  1. Jiunn-Bey Pao
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  2. Ying-Pi Yang
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  3. Chun-Nung Huang
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Corresponding author

Correspondence to Bo-Ying Bao.

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Pao, JB., Yang, YP., Huang, CN. et al. Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer. World J Urol 31, 281–287 (2013). https://doi.org/10.1007/s00345-011-0813-x

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  • DOI: https://doi.org/10.1007/s00345-011-0813-x

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