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Familial risk and familial survival in prostate cancer

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Abstract

Objectives

The Swedish Family-Cancer Database has been the major source of population-based prospective data on familial risks on most cancers, including prostate cancer. In the present review, I focus on three lines of family studies with novel results.

Methods

The covered studies originate from the same database with publication dates spanning a period of somewhat over 3 years. Age-specific hazard ratios (HRs) of incident prostate cancer and fatal prostate cancer were determined according to the number of affected relatives. Cumulative risks for incidence and death were calculated for the various types of families. Finally, data on the familial association of prostate cancer with some other cancers were reviewed.

Results

If the father had prostate cancer, the HR for sons was 2.1 and it increased to 17.7 when three brothers were affected. The highest HR (23) was observed for men before age 60 years with three affected brothers. The patterns for fatal familial prostate cancer were similar. Other reviewed sets of data showed evidence for the familial concordance of good and poor survival in prostate cancer. Familial risks were somewhat higher for fatal than for incident prostate cancer, suggesting that fatal prostate cancers may be a genetic subgroup.

Conclusions

Considering the high familial risks in fatal prostate cancer, family history remains an important prognostic piece of information useful for clinical genetic counseling. Obviously, preventive measures for at-risk men are needed but these are beyond the present paper. Starting screening before any prostate cancers are diagnosed in a family appears counterproductive.

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References

  1. Hemminki K, Sundquist J, Lorenzo Bermejo J (2008) How common is familial cancer. Ann Oncol 19:163–167

    Article  PubMed  CAS  Google Scholar 

  2. Hemminki K, Sundquist J, Lorenzo Bermejo J (2008) Familial risks for cancer as the basis for evidence-based clinical referral and counseling. The Oncologist 13:239–247

    Article  PubMed  Google Scholar 

  3. Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH (1994) Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst 86:1600–1607

    Article  PubMed  CAS  Google Scholar 

  4. Bray F, Klint A, Gislum M et al (2010) Trends in survival of patients diagnosed with male genital cancers in the Nordic countries 1964–2003 followed up until the end of 2006. Acta Oncol 49:644–654

    Article  PubMed  Google Scholar 

  5. Lynch HT, de la Chapelle A (2003) Hereditary colorectal cancer. N Engl J Med 348:919–932

    Article  PubMed  CAS  Google Scholar 

  6. Liede A, Karlan BY, Narod SA (2004) Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature. J Clin Oncol 22:735–742

    Article  PubMed  CAS  Google Scholar 

  7. Amundadottir LT, Thorvaldsson S, Gudbjartsson DF et al (2004) Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family. PLoS Med 1:e65

    Article  PubMed  Google Scholar 

  8. Chung CC, Magalhaes WC, Gonzalez-Bosquet J, Chanock SJ (2010) Genome-wide association studies in cancer–current and future directions. Carcinogenesis 31:111–120

    Article  PubMed  CAS  Google Scholar 

  9. Fletcher O, Houlston RS (2010) Architecture of inherited susceptibility to common cancer. Nat Rev Cancer 10:353–361

    Article  PubMed  CAS  Google Scholar 

  10. Hemminki K, Rawal R, Bermejo JL (2005) Prostate cancer screening, changing age-specific incidence trends and implications on familial risk. Int J Cancer 113:312–315

    Article  PubMed  CAS  Google Scholar 

  11. Brandt A, Bermejo JL, Sundquist J, Hemminki K (2010) Age-specific risk of incident prostate cancer and risk of death from prostate cancer defined by the number of affected family members. Eur Urol 58:275–280

    Article  PubMed  Google Scholar 

  12. Brandt A, Bermejo JL, Sundquist J, Hemminki K (2009) Age at diagnosis and age at death in familial prostate cancer. Oncologist 14:1209–1217

    Article  PubMed  Google Scholar 

  13. Hemminki K, Sundquist J, Brandt A (2011) Familial mortality and familial incidence in cancer. J Clin Oncol 29:712–718

    Article  PubMed  Google Scholar 

  14. Hemminki K, Ji J, Försti A, Sundquist J, Lenner P (2008) Concordance of survival in family members with prostate cancer. J Clin Oncol 26:1705–1709

    Article  PubMed  Google Scholar 

  15. Risbridger GP, Davis ID, Birrell SN, Tilley WD (2010) Breast and prostate cancer: more similar than different. Nat Rev Cancer 10:205–212

    Article  PubMed  CAS  Google Scholar 

  16. Tryggvadottir L, Vidarsdottir L, Thorgeirsson T et al (2007) Prostate cancer progression and survival in BRCA2 mutation carriers. J Natl Cancer Inst 99:929–935

    Article  PubMed  CAS  Google Scholar 

  17. Hemminki K, Forsti A, Chen B (2010) Breast and prostate cancer: familial associations. Nat Rev Cancer 10:523

    Article  PubMed  CAS  Google Scholar 

  18. Brandt A, Sundquist J, Hemminki K (2011) Risk for incident and fatal prostate cancer in men with a family history of any incident and fatal cancer. Ann Oncol (in press)

  19. Johns LE, Houlston RS (2003) A systematic review and meta-analysis of familial prostate cancer risk. BJU Int 91:789–794

    Article  PubMed  CAS  Google Scholar 

  20. Bruner DW, Moore D, Parlanti A, Dorgan J, Engstrom P (2003) Relative risk of prostate cancer for men with affected relatives: systematic review and meta-analysis. Int J Cancer 107:797–803

    Article  PubMed  CAS  Google Scholar 

  21. Thompson IM, Ankerst DP, Tangen CM (2010) Prostate-specific antigen, risk factors, and prostate cancer: confounders nestled in an enigma. J Natl Cancer Inst 102:1299–1301

    Article  PubMed  CAS  Google Scholar 

  22. Bratt O, Garmo H, Adolfsson J et al (2010) Effects of prostate-specific antigen testing on familial prostate cancer risk estimates. J Natl Cancer Inst 102:1336–1343

    Article  PubMed  CAS  Google Scholar 

  23. Lorenzo Bermejo J, Hemminki K (2005) Familial risk of cancer shortly after diagnosis of the first familial tumor. J Natl Cancer Inst 97:1575–1579

    Article  PubMed  Google Scholar 

  24. Welch HG, Black WC (2010) Overdiagnosis in cancer. J Natl Cancer Inst 102:605–613

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Supported by Deutsche Krebshilfe, ALF grants of Region Skane and the Swedish Council for Working Life and Social Research.

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Authors and Affiliations

  1. Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany

    Kari Hemminki

  2. Center for Primary Health Care Research, Lund University, 205 02, Malmö, Sweden

    Kari Hemminki

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  1. Kari Hemminki
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Correspondence to Kari Hemminki.

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Hemminki, K. Familial risk and familial survival in prostate cancer. World J Urol 30, 143–148 (2012). https://doi.org/10.1007/s00345-011-0801-1

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