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Sequence variants of toll-like receptor 4 (TLR4) and the risk of prostate cancer in Korean men

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Abstract

Purpose

Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determine whether they were associated with prostate cancer risk in a Korean cohort.

Methods

An association study between 11 single-nucleotide polymorphisms (SNPs) of the TLR4 gene and prostate cancer was performed in 463 Korean male subjects including 240 prostate cancer patients and 223 healthy controls. SNPs were genotyped using the TaqMan assay, and their association with the risk of prostate cancer was evaluated using logistic regression analysis.

Results

The statistical analysis revealed that one SNP at the 3′UTR (rs11536889) showed significant association with the risk of prostate cancer (P corr = 0.005, OR = 1.81). One common haplotype (ht2) was also significantly associated with the risk of prostate cancer (P corr = 0.009, OR = 1.77). However, further analysis showed no association between any of the SNPs and prostate cancer prognostic factors such as the Gleason score or tumor stage.

Conclusions

The findings of this study suggest that polymorphisms of the TLR4 gene might be associated with the risk of prostate cancer in Korean men.

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Acknowledgments

This work was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare & Family Affairs, the Republic of Korea (A085138).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, South Korea

    Hae Jong Kim, In Ho Chang, Kyung Do Kim, Wonyong Kim & Soon Chul Myung

  2. Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, South Korea

    Hae Jong Kim, Jaehyouk Lee, Wonyong Kim & Soon Chul Myung

  3. Department of Urology, Chung-Ang University College of Medicine, 221 Heukseok-dong Dongjak-ku, Seoul, 156-756, South Korea

    In Ho Chang, Kyung Do Kim & Soon Chul Myung

  4. Laboratory of Genomic Diversity, Department of Life Science, Sogang University, Seoul, South Korea

    Joon Seol Bae & Hyoung Doo Shin

  5. Department of Urology Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea

    Ji Youl Lee

  6. Department of Urology, Chungbuk National University, Cheongju, South Korea

    Wun-Jae Kim

  7. Department of Microbiology, Chung-Ang University College of Medicine, Seoul, South Korea

    Wonyong Kim

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  1. Hae Jong Kim
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Correspondence to Soon Chul Myung.

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Kim, H.J., Bae, J.S., Chang, I.H. et al. Sequence variants of toll-like receptor 4 (TLR4) and the risk of prostate cancer in Korean men. World J Urol 30, 225–232 (2012). https://doi.org/10.1007/s00345-011-0690-3

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  • DOI: https://doi.org/10.1007/s00345-011-0690-3

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