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Typical signs of oncocytic papillary renal cell carcinoma in everyday clinical praxis

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Abstract

Purpose

Types 1 and 2 by Delahunt of papillary renal cell carcinoma (PRCC) are traditionally differentiated. An oncocytic variant of PRCC (O-PRCC) has recently been described. We compare clinical data of O-PRCC with other subtypes of PRCC such as the main tumour size, necrotic changes, presence of pseudocapsula and real extrarenal growth in retrospective study.

Methods

From 1/1992 to 10/2009, 1,398 patients with 1,436 renal tumours were surgically treated in our institution. PRCCs were described in 109 (7.6%). Among PRCC, O-PRCCs were in 12 (11%), PRCC type 1 in 86 (78.9%), PRCC type 2 in 8 (7.3%) and others in 3 (2.8%) cases.

Results

The patient’s mean age with O-PRCC (M:F ratio = 2:1) was 67.5 ± 10.9 versus 63.5 ± 14.1 in type 1 and 57.9 ± 5.7 in type 2, the mean tumour size was 35 ± 12 mm versus 47 ± 22 and 37 ± 17, respectively. The follow-up of O-PRCC is 35.3 ± 12.3 months and all cases are without recurrence. We did not find any pseudocapsula in O-PRCC but it was a major sign of PRCC type 1 (32.6%). Huge microscopic necrotic changes were described in 33.3% of O-PRCC, in 33.7% of PRCC type 1 and 62.5% of PRCC type 2. Extrarenal growth was found only in 16.7% O-PRCC versus 40.7% in PRCC type I.

Conclusions

None of the O-PRCC had pseudocapsula and none had massive necroses in comparison of O-PRCC with PRCC types I and II. Extrarenal growth in O-PRCC is relatively rare. The malignant potential of O-PRCC is low.

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Acknowledgments

The work was supported by Czech government research project MSM 0021620819. 28th February 2010. Authors have not a financial relationship with the organisation that sponsored the research.

Conflict of interest statement

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Authors and Affiliations

  1. Department of Urology, Faculty of Medicine in Pilsen, Charles University in Prague and Faculty Hospital, Dr. E. Benese 13, 30599, Plzen, Czech Republic

    T. Ürge, V. Eret & M. Hora

  2. Department of Pathology, Faculty of Medicine in Pilsen, Charles University in Prague and Faculty Hospital, Dr. E. Benese 13, 30599, Plzen, Czech Republic

    O. Hes & M. Michal

  3. Department of Radiology, Faculty of Medicine in Pilsen, Charles University in Prague and Faculty Hospital, Dr. E. Benese 13, 30599, Plzen, Czech Republic

    J. Ferda & Z. Chudáček

  4. Department of Pathology, University of Verona, Verona, Italy

    M. Brunelli & G. Martignoni

Authors
  1. T. Ürge
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  2. O. Hes
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  3. J. Ferda
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  4. Z. Chudáček
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  5. V. Eret
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  6. M. Michal
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  7. M. Brunelli
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  8. G. Martignoni
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  9. M. Hora
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Correspondence to M. Hora.

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Ürge, T., Hes, O., Ferda, J. et al. Typical signs of oncocytic papillary renal cell carcinoma in everyday clinical praxis. World J Urol 28, 513–517 (2010). https://doi.org/10.1007/s00345-010-0563-1

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  • DOI: https://doi.org/10.1007/s00345-010-0563-1

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