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The NF-κB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?

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Abstract

The nuclear factor of kappa beta (NF-κB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expression are detected in bone metastatic and hormone-refractory prostate cancer. IL-6 has been suggested to have a crucial role in the resistance to chemotherapy or hormonal therapy involving apoptotic cell death. The NF-κB/IL-6 dependent pathways promote tumour-cell survival and in most situations protect cells against apoptotic stimuli. These data provide a rational framework for targeting NF-κB and IL-6 activity in novel biologically based therapies for aggressive and androgen independent prostate cancers.

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Authors and Affiliations

  1. INSERM, Unité 841eq07, IMRB, Department of Immunology Dermatology Oncology, équipe Carcinogénèse et Pathologie Moléculaire des Tumeurs Urologiques, 94010, Créteil, France

    Stéphane Terry, Laurence Kheuang, Pascale Soyeux, Francis Vacherot & Alexandre de la Taille

  2. Faculté de Médecine, Université Paris 12, IFR10, 94010, Créteil, France

    Stéphane Terry, Laurence Kheuang, Pascale Soyeux, Francis Vacherot & Alexandre de la Taille

  3. AP-HP, Groupe Hospitalier Henri Mondor, Service d’Urologie, 94000, Créteil, France

    Bernard Paule & Alexandre de la Taille

  4. INSERM U841EQ07, Department of Urology, CHU Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France

    Alexandre de la Taille

Authors
  1. Bernard Paule
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  2. Stéphane Terry
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  3. Laurence Kheuang
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  4. Pascale Soyeux
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  5. Francis Vacherot
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  6. Alexandre de la Taille
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Corresponding author

Correspondence to Alexandre de la Taille.

Additional information

B. Paule and S. Terry contributed equally to this paper.

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Paule, B., Terry, S., Kheuang, L. et al. The NF-κB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?. World J Urol 25, 477–489 (2007). https://doi.org/10.1007/s00345-007-0175-6

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  • DOI: https://doi.org/10.1007/s00345-007-0175-6

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