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Tissue microarrays: applications in urological cancer research

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Abstract

Tissue microarrays (TMAs) are used to simultaneously study the expression of proteins in hundreds of tissue samples, offering the important advantage to screen large tissue banks for biomarker expression and to simultaneously examine serial sections obtained from the same tumor specimen by a time- and cost-effective analytical approach. This review article presents an overview of the importance and the impact of this technique in cancer research with increasing number of investigations using TMAs in its eighth anniversary. Its application, limitations, and selected previous study results regarding urologic malignancies are presented and discussed.

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Acknowledgments

Supported by a grant from the Federal Ministry of Education and Research (Fö. 01KS9602) and the Interdisciplinary Center of Clinical Research Tübingen (IZKF). Dr Merseburger is supported by a postgraduate grant from the Novartis Foundation.

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Authors and Affiliations

  1. Department of Urology, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany

    A. S. Merseburger, A. G. Anastasiadis, J. Hennenlotter, D. Schilling, A. Stenzl & M. A. Kuczyk

  2. Department of Sports Medicine, Medical Clinic Eberhard Karls University, Tuebingen, Germany

    P. Simon

  3. Department of Urology, Hannover Medical School, Hannover, Germany

    S. A. Machtens & J. Serth

Authors
  1. A. S. Merseburger
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  2. A. G. Anastasiadis
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  3. J. Hennenlotter
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  4. D. Schilling
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  5. P. Simon
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  6. S. A. Machtens
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  7. J. Serth
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  8. A. Stenzl
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  9. M. A. Kuczyk
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Corresponding author

Correspondence to M. A. Kuczyk.

Additional information

A.S. Merseburger and A.G. Anastasiadis have contributed equally to the manuscript.

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Merseburger, A.S., Anastasiadis, A.G., Hennenlotter, J. et al. Tissue microarrays: applications in urological cancer research. World J Urol 24, 579–584 (2006). https://doi.org/10.1007/s00345-006-0103-1

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  • DOI: https://doi.org/10.1007/s00345-006-0103-1

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