Abstract
Laser-induced breakdown spectroscopy (LIBS) is applied to investigate the effect of alcoholism and doping on elemental composition of fingernails of subjects. Measurements are made on 36 fingernail clippings including 8 doping, 8 alcoholic and 20 normal subjects. Classification of normal, alcoholic and doping subjects based on 46 atomic and ionic emission lines belonging to 13 elements of fingernail is examined using discriminant function analysis (DFA) method. The most affecting elements in classification of groups are discussed. In order to improve the repeatability of LIBS measurements, an auto-focus system has been designed and used in experiments. Results are promising and show that by improving the repeatability of experiments through improving the setup, some evidence of the impact of the alcohol and doping on elemental composition of fingernails is observed.
Similar content being viewed by others
References
D.A. Cremers, L.J. Radziemski, Handbook of Laser-Induced Breakdown Spectroscopy (Wiley, Chichester, 2006)
J.P. Singh, S.N. Thakur, Laser-Induced Breakdown Spectroscopy (Elsevier, New York, 2007)
K.E. Eseller, F.Y. Yueh, J.P. Singh, Appl. Phys. B Lasers Opt. 102, 963–969 (2010)
C. Goueguel, S. Laville, F. Vidal, M. Chakera, M. Sabsabi, J. Anal. At. Spectrom. 26, 2452 (2011)
M. Baudelet, L. Guyon, J. Yu, J.P. Wolf, T. Amodeo, E. Fréjafon, P. Laloi, J. Appl. Phys. 99, 084701 (2006)
M. Baudelet, J. Yu, M. Bossu, J. Jovelet, J.P. Wolf, T. Amodeo, E. Fréjafon, P. Laloi, Appl. Phys. Lett. 89, 163903 (2006)
J. Diedrich, S.J. Rehse, S. Palchaudhuri, J. Appl. Phys. 102, 014702 (2007)
J. Diedrich, S.J. Rehse, S. Palchaudhuri, Appl. Phys. Lett. 90, 163901 (2007)
S.J. Rehse, J. Diedrich, S. Palchaudhuri, Spectrochim. Acta, Part B 62, 1169 (2007)
S.J. Rehse, N. Jeyasingham, J. Diedrich, S. Palchaudhuri, J. Appl. Phys. 105, 102034 (2009)
O. Samek, D.C.S. Beddows, H.H. Telle, G.W. Morris, M. Liska, J. Kaiser, Appl. Phys. A 69, S179 (1999)
O. Samek, M. Liska, J. Kaiser, D.C.S. Beddows, H.H. Telle, S.V. Kukhlevsky, J. Clin. Laser Med. Surg. 18, 281 (2000)
M. Corsi, G. Cristoforetti, M. Hidalgo, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, C. Vallebona, J. Appl. Opt. 42, 6133 (2003)
M.A. Kasem, R.E. Russo, M.A. Harith, J. Anal. At. Spectrom. 26, 1733–1739 (2011)
Z. Hosseinimakarem, S.H. Tavassoli, J. Biomed. Opt. 16(5), 057002 (2011)
M. Bahreini, Z. Hosseinimakarem, S.H. Tavassoli, J. Appl. Phys. 112, 054701 (2012)
S. Shadman, M. Bahreini, S. H. Tavassoli, App. Opt. 51(12/20), 2004–2011 (2012)
G.S. Fell, H. Smith, R.A. Howie, J. Clin. Path. 21, 8 (1968)
S. Ohgitani, T. Fujita, Y. Fujii, C. Hayashi, H. Nishio, J. Bone Miner. Metab. 23, 318 (2005)
J.P. Goullé, E. Saussereau, L. Mahieu, D. Bouige, S. Groenwont, M. Guerbet, C. Lacroix, J. Anal. Toxicol. 33(2), 92 (2009)
I. Baranowska, L. Barchański, M. Bąk, B. Smolec, Z. Mzyk, Pol. J. Environ. Stud. 13(6), 639 (2004)
S.K. Biswas, M. Abdullah, S. Akhter, S.A. Tarafdar, M. Khaliquzzaman, A.H. Khan, J. Radioanal. Nucl. Chem. 82/1, 111 (1984)
S.J. Rehse, H. Salimnia, A.W. Miziolek, J. Med. Eng. Technol. 36(2), 77–89 (2012)
V.K. Singh, A.K. Rai, Lasers Med. Sci. 26, 673–687 (2011)
A. Assion, M. Wollenhaupt, L. Haag, F. Mayorov, C. Sarpe-Tudoran, M. Winter, U. Kutschera, T. Baumert, Appl. Phys. B Lasers Opt. 77(4), 391–397 (2003)
Z.A. Abdel-Salam, Z. Nanjing, D. Anglos, M.A. Harith, Appl. Phys. B Lasers Opt. 94, 141–147 (2009)
A.J. Higgins, J. Vet. Pharmacol. Ther. 29(1), 4–8 (2006)
J. O’Leary, Drugs and Doping in Sports—Socio-Legal Perspectives (London, Cavendish Publishing, 2001)
P. Kintz, V. Cirimele, T. Jeanneau, B. Ludes, J. Anal. Toxicol. 23, 352–356 (1999)
H.C. Hopps, Sci. Total Environ. 7, 71 (1977)
R. Baran, R.P.R. Dawber, E. Haneke, A. Tosti, I. Bristow, L. Thomas, A Text Atlas of Nail Disorders: Techniques in Investigation and Diagnosis, Third ed edn. (Martin Dunitz, Taylor & Francis Group, London, 2005)
A. Sukumar, Rev. Environ. Contam. Toxicol. 185, 141–177 (2006)
K. Saito, R. Saito, Y. Kikuchi, Y. Iwasaki, R. Ito, H. Nakazawa, Analysis of drugs of abuse in biological specimens. J. Health Sci. 57(6), 472–487 (2011)
J.Y. Kim, S.H. Shin, M.K. In, Determination of amphetamine-type stimulants, ketamine and metabolites in fingernails by gas chromatography-mass spectrometry. Forensic Sci. Int. 194, 108–114 (2010)
N.P. Lemos, R.A. Anderson, J.R. Robertson, Nail analysis for drugs of abuse: extraction and determination of cannabis in fingernails by RIA and GC-MS. J. Anal. Toxicol. 23, 147–152 (1999)
www.health.am/psy/more/nail-and-hair-sample-show-alcohole-concumtion/
M. Bahreini, S.H. Tavassoli, Possibility of thyroidism diagnosis by laser induced breakdown spectroscopy of human fingernail. Lasers Med. Sci. 3(3), 127–131 (2012)
K. Laitinen, M. Välimäki, Alcohol and bone. Calcif. Tissue Int. 49(Suppl), S70–S73 (1991)
M. Sarli, H. Plotkin, J.R. Zanchetta, Alcoholic osteopathy. Medicina (B Aires) 54(4), 363–370 (1994)
J.L. Davis (2007), Drink less for strong bones [online]. Retrieved July 26, 2010. From http://www.webmd.com/osteoporosis/features/alcohol
American Academy of Orthopaedic Surgeons (2007). What is your risk for osteoporosis? [online]. Retrieved June 21, 2010. From http://orthoinfo.aaos.org/topic.cfm?topic=A00126
E. Murray, Alcohol Health Res. World 21(1), 84–93 (1997)
M.E. Rubini, C.R. Kleeman, E. Lamdin, J. Clin. Invest. 34(3), 439–447 (1955)
Acknowledgments
The authors would like to thank Hossein Ghavaminejad for his kind help in collection of fingernails. We are also thankful of every person who participates in this study by giving the fingernail clippings.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bahreini, M., Ashrafkhani, B. & Tavassoli, S.H. Elemental analysis of fingernail of alcoholic and doping subjects by laser-induced breakdown spectroscopy. Appl. Phys. B 114, 439–447 (2014). https://doi.org/10.1007/s00340-013-5538-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00340-013-5538-7