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Electrical imaging of neuronal activity by multi-transistor-array (MTA) recording at 7.8 μm resolution

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Abstract

We report on a novel method for two-dimensional electrical mapping of neuronal activity using a 1 mm2 array of 16384 sensor field-effect transistors fabricated by an extended CMOS (complementary metal oxide silicon) technology. The contact from neurons to chip is made by an insulating oxide on the chip surface that provides a purely capacitive drive of the sensor transistors. As a test system for multi-transistor-array (MTA) recording we use cultured neurons from the pond snail. We present electrical maps of an individual neuron and of a small neuronal network at a resolution of 7.8 μm. MTA recording provides a tool for imaging the network dynamics of cultured nerve cells and brain slices for studies in neurobiology and biosensorics.

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Authors and Affiliations

  1. Department of Membrane and Neurophysics, Max Planck Institute for Biochemistry, 82152, Martinsried/München, Germany

    A. Lambacher, M. Merz, R.A. Kaul & P. Fromherz

  2. Corporate Research, Infineon Technologies AG, 81669, München, Germany

    M. Jenkner, B. Eversmann, F. Hofmann & R. Thewes

Authors
  1. A. Lambacher
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  2. M. Jenkner
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  3. M. Merz
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  4. B. Eversmann
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  5. R.A. Kaul
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  6. F. Hofmann
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  7. R. Thewes
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  8. P. Fromherz
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Corresponding author

Correspondence to P. Fromherz.

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PACS

87.17.Nn, 87.80.Xa, 73.40.Mr

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Lambacher, A., Jenkner, M., Merz, M. et al. Electrical imaging of neuronal activity by multi-transistor-array (MTA) recording at 7.8 μm resolution. Appl Phys A 79, 1607–1611 (2004). https://doi.org/10.1007/s00339-004-2991-5

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  • DOI: https://doi.org/10.1007/s00339-004-2991-5

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