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Sex-restricted non-Mendelian inheritance of mouse Chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J × DBA/2J)F1 mice

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Abstract.

We report on the observation of sex-restricted, non-Mendelian inheritance over a region of mouse Chromosome (Chr) 11, occurring in the offspring of crosses between two commonly used Mus musculus-derived inbred strains, C57BL/6J and DBA/2J. In the surviving backcross progeny of reciprocal matings between (C57BL/6J × DBA/2J)F1 hybrids and the C57BL/6J parental strain, we observed the preferential appearance of C57BL/6J alleles along a region of Chr 11. The deviation from Mendelian predictions was observed only in female offspring from both reciprocal backcrosses, and not in males from either cross. The sex-specificity of the observed non-Mendelian inheritance points to an explanation based on embryonic or neonatal lethality. Our data add to previously obtained evidence for a Chr 11 locus or loci with sex-specific and allele-specific effects on viability.

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Authors and Affiliations

  1. Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA, , , , , , US

    Jay Shendure, Justine A. Melo, Kara Pociask, Rachel Derr & Lee M. Silver

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  1. Jay Shendure
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  2. Justine A. Melo
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  3. Kara Pociask
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  4. Rachel Derr
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  5. Lee M. Silver
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Received: 19 December 1997 / Accepted: 10 June 1998

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Shendure, J., Melo, J., Pociask, K. et al. Sex-restricted non-Mendelian inheritance of mouse Chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J × DBA/2J)F1 mice. 9, 812–815 (1998). https://doi.org/10.1007/s003359900872

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  • DOI: https://doi.org/10.1007/s003359900872

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