Skip to main content
SpringerLink
Log in

Genomic structure of the human KDR/flk-1 gene

  • Short Communications
  • Published:
Mammalian Genome Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Davis-Smyth T, Chen H, Park J, Presta LG, Ferrara N (1996) The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J 15, 4919–4927

    PubMed  CAS  Google Scholar 

  • Fong GH, Rossant J, Gertsenstein M, Breitman ML (1995) Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66–70

    Article  PubMed  CAS  Google Scholar 

  • Giebel LB, Strunk KM, Holmes SA, Spritz RA (1992) Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene. Oncogene 7, 2207–2217

    PubMed  CAS  Google Scholar 

  • Heideran MA, Pierce JH, Jensen RA, Matsui T, Aaronson SA (1990) Chimeric α and β-platelet derived growth factor (PDGF) receptors define three immunoglobulin-like domains of the α-PDGF receptor and determine PDGF-AA binding specificity. J Biol Chem 265, 18741–18744

    Google Scholar 

  • Kawagishi J, Kumabe T, Yoshimoto T, Yamamoto T (1995) Structure, organization, and transcription units of the human α-platelet-derived growth factor receptor gene, PDGFRA. Genomics 30, 224–232

    Article  PubMed  CAS  Google Scholar 

  • Matthews W, Jordan CT, Gavin M, Jenkins NA, Copeland NG, Lemischka IR (1991) A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci USA 88, 9026–9030

    Article  PubMed  CAS  Google Scholar 

  • Patterson C, Perrella MA, Hsieh C-M, Yoshizumi M, Lee M-E, Haber E (1995) Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem 270, 23111–23118

    Article  PubMed  CAS  Google Scholar 

  • Patterson C, Perrella MA, Endege WO, Yoshizumi M, Lee M-E, Haber E (1996) Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-α in cultured human vascular endothelial cells. J Clin Invest 98, 490–496

    Article  PubMed  CAS  Google Scholar 

  • Patterson C, Wu Y, Lee M-E, DeVault JD, Runge MS, Haber E (1997) Nuclear protein interactions with the human KDR/flk-1 promoter in vivo. J Biol Chem 272, 8410–8416

    Article  PubMed  CAS  Google Scholar 

  • Pepper MS (1997) Manipulating angiogenesis. Circ Res 17, 605–619.

    CAS  Google Scholar 

  • Rosnet O, Stephenson D, Mattei M-G, Marchetto S, Shibuya M, Chapman VM, Birnbaum D (1993) Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse. Oncogene 8, 173–179

    PubMed  CAS  Google Scholar 

  • Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu X-F, Breitman M, Schuh A (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376, 62–66

    Article  PubMed  CAS  Google Scholar 

  • Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (1990) Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5, 519–524

    PubMed  CAS  Google Scholar 

  • Spritz RA, Strunk KM, Lee S-T, Lu-kuo JM, Ward DC, le Paslier D, Altherr MR, Dorman TE, Moir DT (1994). A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. Genomics 22, 431–436

    Article  PubMed  CAS  Google Scholar 

  • Sternberg NL (1992) Cloning high molecular weight DNA fragments by the bacteriophage P1 system. Trends Genet 8, 11–16

    Article  PubMed  CAS  Google Scholar 

  • Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB (1991) Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6, 1677–1683

    PubMed  CAS  Google Scholar 

  • Ullrich A, Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203–212

    Article  PubMed  CAS  Google Scholar 

  • Vikkula M, Boon LM, Carraway KL, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA, Marchuk DA, Warman ML, Cantley LC, Mulliken JB, Olsen BR (1996) Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 87, 1181–1190

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiology, University of Texas Medical Branch at Galveston, 301 University Boulevard, 9.138 Medical Research Building, 77555-1064, Galveston, Texas, USA

    Li-Yan Yin, Yaxu Wu, Carol A. Ballinger & Cam Patterson

Authors
  1. Li-Yan Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yaxu Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carol A. Ballinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cam Patterson
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The nucleotide sequence data reported in the paper have been submitted to GenBank and have been assigned the accession number AF035121.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yin, LY., Wu, Y., Ballinger, C.A. et al. Genomic structure of the human KDR/flk-1 gene. Mammalian Genome 9, 408–410 (1998). https://doi.org/10.1007/s003359900783

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s003359900783

Keywords

Search

Navigation