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Polymorphism at the bovine tumor necrosis factor alpha locus and assignment to BTA 23

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Abstract

We have identified four single-strand conformation variants of the bovine tumor necrosis factor alpha gene by analysis of PCR-amplified fragments. The variants are inherited in Mendelian fashion and are informative for linkage mapping. We have mapped the bovine gene to Chromosome (Chr) 23 in a panel of somatic cell hybrids and observed genetic linkage to the major histocompatibility complex (BoLA) genes and microsatellite markers on bovine Chr 23 in an international bovine reference family panel. The distribution of the alleles was determined in cattle of different breeds and of different geographical origins, which included trypano-susceptible and trypano-tolerant cattle.

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Authors and Affiliations

  1. International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya

    M. Agaba & A. J. Teale

  2. Dept. of Genetics and Microbiology, University of Liverpool, Donnan Laboratories, L69 3BX, Liverpool, UK

    S. J. Kemp

  3. CSIRO Division of Tropical Animal Production, Molecular Animal Genetics Centre, Gehrmann Laboratories, University of Queensland, Research Rd., Qld 4072, Brisbane, Australia

    W. Barendse

Authors
  1. M. Agaba
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  2. S. J. Kemp
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  3. W. Barendse
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  4. A. J. Teale
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Agaba, M., Kemp, S.J., Barendse, W. et al. Polymorphism at the bovine tumor necrosis factor alpha locus and assignment to BTA 23. Mammalian Genome 7, 186–187 (1996). https://doi.org/10.1007/s003359900051

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  • DOI: https://doi.org/10.1007/s003359900051

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