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A deletion on Chromosome 4 cosegregates with the whirler deafness mutation: exclusion of Orm1 as a candidate

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Abstract.

Whirler (wi) mice display profound deafness and a head-tossing and circling phenotype, showing an autosomal recessive mode of inheritance. The wi mutation has been shown to map close to the Orm gene cluster on mouse Chromosome (Chr) 4. We have, therefore, investigated the Orm loci as candidates for the whirler gene. Detailed mapping and analysis of the Orm gene cluster in both normal and whirler mice indicates the presence of a <48-kb deletion in whirler mice that disrupts the Orm1 locus. The Orm1 locus is also deleted in the CE/J mouse strain, and we discuss the candidature of Orm1 for the whirler gene.

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Authors and Affiliations

  1. MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, Didcot, Oxon OX11 0RD, UK, GB

    Adam J.W. Paige, Anabel Varela & Steve D.M. Brown

  2. MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK, GB

    Brent W. Kiernan, Michael J.C. Rogers, David Hughes & Karen P. Steel

Authors
  1. Adam J.W. Paige
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  2. Brent W. Kiernan
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  3. Anabel Varela
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  4. Michael J.C. Rogers
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  5. David Hughes
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  6. Karen P. Steel
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  7. Steve D.M. Brown
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Received: 22 June 1999 / Accepted: 17 September 1999

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Paige, A., Kiernan, B., Varela, A. et al. A deletion on Chromosome 4 cosegregates with the whirler deafness mutation: exclusion of Orm1 as a candidate. Incorporating Mouse Genome 11, 51–57 (2000). https://doi.org/10.1007/s003350010010

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  • DOI: https://doi.org/10.1007/s003350010010

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