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The intertwined fates of inflammation and coagulation in glioma

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Abstract

Inflammation and coagulation are two intertwined pathways with evolutionary ties being traced back to the hemocyte, a single cell type in invertebrates that has functions in both the inflammatory and coagulation pathways. These systems have functioned together throughout evolution to provide a solid defence against infection, damaged cells and irritants. While these systems work in harmony the majority of the time, they can also become dysregulated or corrupted by tumours, enhancing tumour proliferation, invasion, dissemination and survival. This review aims to give a brief overview of how these systems work in harmony and how dysregulation of these systems aids in the development and progression of cancer, using glioma as an example.

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Funding

K. McKelvey is supported by The Brain Cancer Group, Sydney Vital Translational Cancer Centre, and Matt Callander Beanie for Brain Cancer Fellowship, Mark Hughes Foundation, Hunter Medical Research Institute; A Cho and A Hudson are supported by The Brain Cancer Group.

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Authors and Affiliations

  1. The Brain Cancer Group, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, St Leonards, NSW, 2065, Australia

    Angela Cho, Kelly J. McKelvey, Adrian Lee & Amanda L. Hudson

  2. Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia

    Angela Cho, Kelly J. McKelvey, Adrian Lee & Amanda L. Hudson

  3. Sydney Medical School Northern, University of Sydney, Camperdown, NSW, 2065, Australia

    Angela Cho, Kelly J. McKelvey, Adrian Lee & Amanda L. Hudson

Authors
  1. Angela Cho
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  2. Kelly J. McKelvey
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  3. Adrian Lee
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  4. Amanda L. Hudson
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Correspondence to Amanda L. Hudson.

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Cho, A., McKelvey, K.J., Lee, A. et al. The intertwined fates of inflammation and coagulation in glioma. Mamm Genome 29, 806–816 (2018). https://doi.org/10.1007/s00335-018-9761-8

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