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Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors

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Abstract

Cytomegaloviruses (CMV) are ubiquitous, opportunistic DNA viruses that have mastered the art of immune evasion through their ability to mimic host proteins or to inhibit antiviral responses. The study of the host response against CMV infection has illuminated many facets of the complex interaction between host and pathogen. Here, we review evidence derived from the animal models and human studies that supports the central role played by innate immune receptors in the recognition of virus infection and their participation in the many layers of defense.

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Acknowledgments

We apologize to our colleagues who were not cited here due to lack of space. This work was supported by the Canadian Institutes of Health Research MOP-7781, as well as the Canadian Institutes of Health Doctoral Scholarship (M. Pyzik) and the Canada Research Chairs Program (S. M. Vidal).

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Authors and Affiliations

  1. Department of Human Genetics and Centre for the Study of Host Resistance, McGill University, Montreal, QC, H3G 0B1, Canada

    Michal Pyzik, Eve-Marie Gendron-Pontbriand, Nassima Fodil-Cornu & Silvia M. Vidal

  2. Department of Microbiology and Immunology, McGill University, Montreal, QC, H3G 0B1, Canada

    Silvia M. Vidal

  3. The McGill Life Sciences Complex, 3649 Promenade Sir William Osler, Montreal, QC, H3G 0B1, Canada

    Silvia M. Vidal

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  1. Michal Pyzik
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  2. Eve-Marie Gendron-Pontbriand
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  3. Nassima Fodil-Cornu
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  4. Silvia M. Vidal
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Correspondence to Silvia M. Vidal.

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Pyzik, M., Gendron-Pontbriand, EM., Fodil-Cornu, N. et al. Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors. Mamm Genome 22, 6–18 (2011). https://doi.org/10.1007/s00335-010-9286-2

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  • DOI: https://doi.org/10.1007/s00335-010-9286-2

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