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HCOP: The HGNC comparison of orthology predictions search tool

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Abstract

The HGNC Comparison of Orthology Predictions search tool, HCOP (http://www.gene.ucl.ac.uk/cgi-bin/nomenclature/hcop.pl), enables users to compare predicted human and mouse orthologs for a specified gene, or set of genes, from either species according to the ortholog assertions from the Ensembl, HGNC, Homologene, Inparanoid, MGI and PhIGs databases. Users can assess the reliability of the prediction from the number of these different sources that identify a particular orthologous pair. HCOP provides a useful one-stop resource to summarise, compare and access various sources of human and mouse orthology data.

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References

  • Dehal P, Boore JL (2005) Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate. PLoS Biol 3: e314

    Article  PubMed  Google Scholar 

  • Eppig JT, Bult CJ, Kadin JA, Richardson JE, Blake JA, Anagnostopoulos A, et al. (2005) The Mouse Genome Database (MGD): from genes to mice–a community resource for mouse biology. Nucleic Acids Res 33(Database issue): D471–D475

    PubMed  CAS  Google Scholar 

  • Hubbard T, Andrews D, Caccamo M, Cameron G, Chen Y, Clamp M, et al. (2005) Ensembl 2005. Nucleic Acids Res 33(Database issue): D447–D453

    PubMed  CAS  Google Scholar 

  • O’Brien KP, Remm M, Sonnhammer EL (2005) Inparanoid: a comprehensive database of eukaryotic orthologs. Nucleic Acids Res 33(Database issue): D476–D480

    PubMed  CAS  Google Scholar 

  • Pruitt KD, Tatusova T, Maglott DR (2005) NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res 33(Database issue): D501–D504

    PubMed  CAS  Google Scholar 

  • Remm M, Storm CE, Sonnhammer EL (2001) Automatic clustering of orthologs and in-paralogs from pairwise species comparisons. J Mol Biol 314: 1041–1052

    Article  PubMed  CAS  Google Scholar 

  • Wain HM, Lush MJ, Ducluzeau F, Khodiyar VK, Povey S (2004) Genew: the Human Gene Nomenclature Database, 2004 updates. Nucleic Acids Res 32 (Database issue): D255–D257

    PubMed  CAS  Google Scholar 

  • Wheeler DL, Barrett T, Benson DA, Bryant SH, Canese K, Church DM, et al. (2005) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 33(Database issue): D39–D45

    PubMed  CAS  Google Scholar 

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Acknowledgment

HCOP has been developed as part of the Human & Mouse Orthologous Gene Nomenclature (HUMOT) project (http://www.gene.ucl.ac.uk/nomenclature/humot) which is funded by the Wellcome Trust. The work of the HGNC is also supported by NHGRI grant P41 HG003345 and the UK Medical Research Council.

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Authors and Affiliations

  1. HUGO Gene Nomenclature Committee, The Galton Laboratory, Department of Biology, University College London, Wolfson House, 4, Stephenson Way, London, NW1 2HE, UK

    Mathew W. Wright, Tina A. Eyre, Michael J. Lush, Sue Povey & Elspeth A. Bruford

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  1. Mathew W. Wright
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  2. Tina A. Eyre
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  3. Michael J. Lush
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  4. Sue Povey
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  5. Elspeth A. Bruford
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Correspondence to Mathew W. Wright.

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Wright, M.W., Eyre, T.A., Lush, M.J. et al. HCOP: The HGNC comparison of orthology predictions search tool . Mamm Genome 16, 827–828 (2005). https://doi.org/10.1007/s00335-005-0103-2

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  • DOI: https://doi.org/10.1007/s00335-005-0103-2

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