Abstract
Matsumoto Eosinophilia Shinshu (MES) is a rat strain that spontaneously develops eosinophilia and eosinophil-related inflammatory lesions in many organs. We performed chromosomal mapping of the gene for eosinophilia by breeding backcross progeny. The onset of eosinophilia appeared to be delayed in the progeny compared with that in MES, with the prevalence of eosinophilia in the backcross progeny at 12 weeks of age being 22.5%. Genetic linkage analysis with marker loci indicated the major locus for eosinophilia was located at the end of the q arm region of Chromosome 19 (between D19Rat8 and telomere). The locus was denoted eosinophilia 1 (eos1). These data will form the basis for identification of the eos1 gene using a reverse genetic approach, which will hopefully lead to elucidation of the mechanisms involved in eosinophilia and eosinophilopoiesis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brito–Babapulle F (2003) The eosinophilias, including the idiopathic hypereosinophilic syndrome Br J Haematol 121: 203–223
Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, et al. (2003) A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinibe in idiopathic hypereosinophilic syndrome N Engl J Med 348: 1201–1214
Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R (2003) Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome Proc Natl Acad Sci USA 100: 7830–7835
Holtschke T, Lohler J, Kanno Y, Fehr T, Giese N, et al. (1996) Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene Cell 87: 307–317
Lin AY, Nutman TB, Kaslow D, Mulvihill JJ, Fontaine L, et al. (1998) Familial eosinophilia: clinical and laboratory results on a U.S. kindred Am J Med Genet 76: 229–237
Manley KF, Cudmore RH Jr, Meer JM (2001) Map Manager QTX, cross-platform software for genetic mapping Mamm Genome 12: 930–932
Matsumoto K, Matsushita N, Tomozawa H, Tagawa Y (2000) Hematological characteristics of rats spontaneously developing eosinophilia Exp Anim 49: 211–215
Muto S, Hayashi M, Matsushita N, Momose Y, Shibata N, et al. (2001) Systemic and eosinophilic lesions in rats with spontaneous eosinophilia (mes rats) Vet Pathol 38: 346–350
Muto S, Kawakubo M, Matsushita N, Maeda N, Momose Y, et al. (2005) Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyzer Lab Anim 39: 122–129
Muto S, Kawakubo M, Matsushita N, Maeda N, Momose Y, et al. (2005) Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyzer Lab Anim 39: 122–129
Rioux JD, Stone VA, Daly MJ, Cargill M, Green T, et al. (1998) Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31–q33 Am J Hum Genet 63: 1086–1994
Roufosse F, Cogan E, Goldman M (2004) Recent advances in pathogenesis and management of hypereosinophilic syndromes Allergy 59: 673–689
Sano K, Kobayashi M, Sakaguchi N, Ito M, Hotchi M, et al. (2001) A rat model of hypereosinophilic syndrome Pathol Int 51: 82–88
Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, et al. (1997) FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation Cell 90: 109–119
Acknowledgment
This work was supported in part by Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan (11680819 to M.M. and K.H).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, G., Guo, Z., Higuchi, K. et al. A locus for eosinophilia in the MES rat is on Chromosome 19. Mamm Genome 16, 516–523 (2005). https://doi.org/10.1007/s00335-004-2454-5
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00335-004-2454-5