Skip to main content
SpringerLink
Log in

Three ATP-binding cassette transporter genes, Abca14, Abca15, and Abca16, form a cluster on mouse Chromosome 7F3

  • Original Contributions
  • Published:
Mammalian Genome Aims and scope Submit manuscript

Abstract

We have identified and cloned three mouse genes that belong to the ABCA subfamily of ATP-binding cassette (ABC) transporters. These three genes are arranged in a tandem head-to-tail cluster spanning about 300 kb on mouse Chromosome (Chr) 7F3. Phylogenetic analysis indicates that although the three genes are related to human and mouse ABCA3, they are not orthologs of any of the current list of 48 human ABC genes and were, therefore, named Abca14, Abca15, and Abca16. The coding region of each gene is split into 31 exons, has an open reading frame of more than 1600 amino acids, and encodes a full transporter molecule with two nucleotide-binding folds (NBF) and two transmembrane domains (TMD). All three genes are predominantly expressed in testis, which suggests that they may perform special functions in testicular development or spermatogenesis. Interestingly, the human genome contains only fragments (less than ten exons) of at least two different ABC genes in the syntenic region on Chromosome 16p12 that are scattered among other, unrelated genes and are not capable of coding functional ABC transporters.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • R Allikmets B Gerrard A Hutchinson M Dean (1996) ArticleTitleCharacterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database Hum Mol Genet 5 1649–1655 Occurrence Handle10.1093/hmg/5.10.1649 Occurrence Handle1:CAS:528:DyaK28Xmt1ant7s%3D Occurrence Handle8894702

    Article  CAS  PubMed  Google Scholar 

  • R Allikmets N Singh H Sun NF Shroyer A Hutchinson et al. (1997) ArticleTitleA photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy Nat Genet 15 236–246 Occurrence Handle1:CAS:528:DyaK2sXhsVGmsL0%3D Occurrence Handle9054934

    CAS  PubMed  Google Scholar 

  • T Annilo ZQ Chen S Shulenin M Dean (2003) ArticleTitleEvolutionary analysis of a cluster of ATP-binding cassette (ABC) genes Mamm Genome 14 7–20 Occurrence Handle10.1007/s00335-002-2229-9 Occurrence Handle1:CAS:528:DC%2BD3sXltlCjtg%3D%3D Occurrence Handle12532264

    Article  CAS  PubMed  Google Scholar 

  • KE Berge H Tian GA Graf L Yu NV Grishin et al. (2000) ArticleTitleAccumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science 290 1771–1775 Occurrence Handle10.1126/science.290.5497.1771 Occurrence Handle1:CAS:528:DC%2BD3cXovVOhurg%3D Occurrence Handle11099417

    Article  CAS  PubMed  Google Scholar 

  • P Borst RO Elferink (2002) ArticleTitleMammalian ABC transporters in health and disease Annu Rev Biochem 71 537–592 Occurrence Handle10.1146/annurev.biochem.71.102301.093055 Occurrence Handle1:CAS:528:DC%2BD38Xos1Clt74%3D Occurrence Handle12045106

    Article  CAS  PubMed  Google Scholar 

  • A Brooks-Wilson M Marcil SM Clee LH Zhang K Roomp et al. (1999) ArticleTitleMutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency Nat Genet 22 336–345 Occurrence Handle1:CAS:528:DyaK1MXltVSht7c%3D Occurrence Handle10431236

    CAS  PubMed  Google Scholar 

  • Dean M (2002) The Human ATP-Binding Cassette (ABC) Transporter Superfamily. NCBI, National Library of Medicine (US), Bethesda, MD

  • M Dean MB White J Amos B Gerrard C Stewart et al. (1990) ArticleTitleMultiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients Cell 61 863–870 Occurrence Handle1:CAS:528:DyaK3cXktlyntrg%3D Occurrence Handle2344617

    CAS  PubMed  Google Scholar 

  • M Dean A Rzhetsky R Allikmets (2001) ArticleTitleThe human ATP-binding cassette (ABC) transporter superfamily Genome Res 11 1156–1166 Occurrence Handle10.1101/gr.GR-1649R Occurrence Handle1:CAS:528:DC%2BD3MXltFaitL0%3D Occurrence Handle11435397

    Article  CAS  PubMed  Google Scholar 

  • JF Deleuze E Jacquemin C Dubuisson D Cresteil M Dumont et al. (1996) ArticleTitleDefect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis Hepatology 23 904–908 Occurrence Handle10.1053/jhep.1996.v23.pm0008666348 Occurrence Handle1:CAS:528:DyaK28XisFygtL0%3D Occurrence Handle8666348

    Article  CAS  PubMed  Google Scholar 

  • MM Gottesman T Fojo SE Bates (2002) ArticleTitleMultidrug resistance in cancer: role of ATP-dependent transporters Nat Rev Cancer 2 48–58 Occurrence Handle10.1038/nrc706 Occurrence Handle1:CAS:528:DC%2BD38XhvF2jtL8%3D Occurrence Handle11902585

    Article  CAS  PubMed  Google Scholar 

  • I Klein B Sarkadi A Varadi (1999) ArticleTitleAn inventory of the human ABC proteins Biochim Biophys Acta 1461 237–262 Occurrence Handle1:CAS:528:DyaK1MXns1agtLs%3D Occurrence Handle10581359

    CAS  PubMed  Google Scholar 

  • S Kumar K Tamura IB Jakobsen M Nei (2001) ArticleTitleMEGA2: molecular evolutionary genetics analysis software Bioinformatics 17 1244–1245 Occurrence Handle1:CAS:528:DC%2BD38XmtVCktQ%3D%3D Occurrence Handle11751241

    CAS  PubMed  Google Scholar 

  • ES Lander LM Linton B Birren C Nusbaum MC Zody et al. (2001) ArticleTitleInitial sequencing and analysis of the human genome Nature 409 860–921 Occurrence Handle1:CAS:528:DC%2BD3MXhsFCjtLc%3D Occurrence Handle11237011

    CAS  PubMed  Google Scholar 

  • MH Lee K Lu S Hazard H Yu S Shulenin et al. (2001) ArticleTitleIdentification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption Nat Genet 27 79–83 Occurrence Handle1:CAS:528:DC%2BD3MXis1ykuw%3D%3D Occurrence Handle11138003

    CAS  PubMed  Google Scholar 

  • KJ Mengerink VD Vacquier (2002) ArticleTitleAn ATP-binding cassette transporter is a major glycoprotein of sea urchin sperm membranes J Biol Chem 277 40729–40734 Occurrence Handle10.1074/jbc.M207184200 Occurrence Handle1:CAS:528:DC%2BD38XnvFyntbw%3D Occurrence Handle12193601

    Article  CAS  PubMed  Google Scholar 

  • J Mosser AM Douar CO Sarde P Kioschis R Feil et al. (1993) ArticleTitlePutative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters Nature 361 726–730 Occurrence Handle1:CAS:528:DyaK3sXmt1ehurk%3D Occurrence Handle8441467

    CAS  PubMed  Google Scholar 

  • S Mulugeta JM Gray KL Notarfrancesco LW Gonzales M Koval et al. (2002) ArticleTitleIdentification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3 J Biol Chem 277 22147–22155 Occurrence Handle10.1074/jbc.M201812200 Occurrence Handle1:CAS:528:DC%2BD38XltVGks7w%3D Occurrence Handle11940594

    Article  CAS  PubMed  Google Scholar 

  • F Peelman C Labeur B Vanloo S Roosbeek C Devaud et al. (2003) ArticleTitleCharacterization of the ABCA transporter subfamily: identification of prokaryotic and eukaryotic members, phylogeny and topology J Mol Biol 325 259–274 Occurrence Handle10.1016/S0022-2836(02)01105-1 Occurrence Handle1:CAS:528:DC%2BD38XpsFyitLc%3D Occurrence Handle12488094

    Article  CAS  PubMed  Google Scholar 

  • C Prades I Arnould T Annilo S Shulenin ZQ Chen et al. (2002) ArticleTitleThe human ATP binding cassette gene ABCA13, located on chromosome 7p12.3, encodes a 5058 amino acid protein with an extracellular domain encoded in part by a 4.8-kb conserved exon Cytogenet Genome Res 98 160–168 Occurrence Handle10.1159/000069852 Occurrence Handle1:CAS:528:DC%2BD3sXivFOhs70%3D Occurrence Handle12697998

    Article  CAS  PubMed  Google Scholar 

  • AT Remaley S Rust M Rosier C Knapper L Naudin et al. (1999) ArticleTitleHuman ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred Proc Natl Acad Sci USA 96 12685–12690 Occurrence Handle10.1073/pnas.96.22.12685 Occurrence Handle1:CAS:528:DyaK1MXnt1yqsLo%3D Occurrence Handle10535983

    Article  CAS  PubMed  Google Scholar 

  • JR Riordan JM Rommens B Kerem N Alon R Rozmahel et al. (1989) ArticleTitleIdentification of the cystic fibrosis gene: cloning and characterization of complementary DNA Science 245 1066–1073 Occurrence Handle1:CAS:528:DyaK3cXhvFarur0%3D Occurrence Handle2475911

    CAS  PubMed  Google Scholar 

  • S Rust M Rosier H Funke J Real Z Amoura et al. (1999) ArticleTitleTangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 Nat Genet 22 352–355 Occurrence Handle10.1038/11921 Occurrence Handle1:CAS:528:DyaK1MXltVShtb0%3D Occurrence Handle10431238

    Article  CAS  PubMed  Google Scholar 

  • G Schmitz WE Kaminski (2002) ArticleTitleABCA2: a candidate regulator of neural transmembrane lipid transport Cell Mol Life Sci 59 1285–1295 Occurrence Handle10.1007/s00018-002-8508-5

    Article  Google Scholar 

  • MS Springer WJ Murphy E Eizirik SJ O‘Brien (2003) ArticleTitlePlacental mammal diversification and the Cretaceous-Tertiary boundary Proc Natl Acad Sci USA 100 1056–1061 Occurrence Handle1:CAS:528:DC%2BD3sXhtF2gtrw%3D Occurrence Handle12552136

    CAS  PubMed  Google Scholar 

  • SS Strautnieks LN Bull AS Knisely SA Kocoshis N Dahl et al. (1998) ArticleTitleA gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis Nat Genet 20 233–238 Occurrence Handle1:CAS:528:DyaK1cXntFOjs78%3D Occurrence Handle9806540

    CAS  PubMed  Google Scholar 

  • AR Tanaka Y Ikeda S Abe-Dohmae R Arakawa K Sadanami et al. (2001) ArticleTitleHuman ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren’s syndrome Biochem Biophys Res Commun 283 1019–1025 Occurrence Handle10.1006/bbrc.2001.4891 Occurrence Handle1:CAS:528:DC%2BD3MXjsFWht7Y%3D Occurrence Handle11355874

    Article  CAS  PubMed  Google Scholar 

  • JC Venter MD Adams EW Myers PW Li RJ Mural et al. (2001) ArticleTitleThe sequence of the human genome Science 291 1304–1351 Occurrence Handle1:CAS:528:DC%2BD3MXhtlSgsbo%3D Occurrence Handle11181995

    CAS  PubMed  Google Scholar 

  • G Yamano H Funahashi O Kawanami LX Zhao N Ban et al. (2001) ArticleTitleABCA3 is a lamellar body membrane protein in human lung alveolar type II cells FEBS Lett 508 221–225 Occurrence Handle10.1016/S0014-5793(01)03056-3 Occurrence Handle1:CAS:528:DC%2BD3MXosFKqtrs%3D Occurrence Handle11718719

    Article  CAS  PubMed  Google Scholar 

Web site reference

Download references

Acknowledgments

Portions of the data analysis were performed at the Advanced Biomedical Computing Center, NCI-Frederick. This publication has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract N. NO1-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Author information

Authors and Affiliations

  1. Basic Research Program, SAIC-Frederick, NCI-Frederick, Maryland, 21702, USA

    Zhang-qun Chen

  2. Human Genetics Section, Laboratory of Genomic Diversity, NCI-Frederick, Maryland, 21702, USA

    Tarmo Annilo, Sergey Shulenin & Michael Dean

Authors
  1. Zhang-qun Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tarmo Annilo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sergey Shulenin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael Dean
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael Dean.

Additional information

(Zhang-qun Chen and Tarmo Annilo) These authors contributed equally to this study.

Sequence data from this article have been deposited with the DDBJ/EMBL/GenBank Data Libraries under accession numbers AY243470–AY243472.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, Zq., Annilo, T., Shulenin, S. et al. Three ATP-binding cassette transporter genes, Abca14, Abca15, and Abca16, form a cluster on mouse Chromosome 7F3. Mamm Genome 15, 335–343 (2004). https://doi.org/10.1007/s00335-004-2281-8

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00335-004-2281-8

Keywords

Search

Navigation