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Value of 3-T MR imaging in intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma

  • Gastrointestinal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To examine the value of 3-T MRI for evaluating the difference between the pancreatic parenchyma of intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma (IPMN-IC) and the pancreatic parenchyma of patients without an IPMN-IC.

Methods

A total of 132 patients underwent abdominal 3-T MRI. Of the normal pancreatic parenchymal measurements, the pancreas-to-muscle signal intensity ratio in in-phase imaging (SIR-I), SIR in opposed-phase imaging (SIR-O), SIR in T2-weighted imaging (SIR-T2), ADC (×10−3 mm2/s) in DWI, and proton density fat fraction (PDFF [%]) in multi-echo 3D DIXON were calculated. The patients were divided into three groups (normal pancreas group: n = 60, intraductal papillary mucinous neoplasm (IPMN) group: n = 60, IPMN-IC group: n = 12).

Results

No significant differences were observed among the three groups in age, sex, body mass index, prevalence of diabetes mellitus, and hemoglobin A1c (p = 0.141 to p = 0.657). In comparisons among the three groups, the PDFF showed a significant difference (p < 0.001), and there were no significant differences among the three groups in SIR-I, SIR-O, SIR-T2, and ADC (p = 0.153 to p = 0.684). The PDFF of the pancreas was significantly higher in the IPMN-IC group than in the normal pancreas group or the IPMN group (p < 0.001 and p < 0.001, respectively), with no significant difference between the normal pancreas group and the IPMN group (p = 0.916).

Conclusions

These observations suggest that the PDFF of the pancreas is associated with the presence of IPMN-IC.

Key Points

• The cause and risk factors of IPMN with a concomitant invasive carcinoma have not yet been clarified.

• The PDFF of the pancreas was significantly higher in the IPMN-IC group than in the normal pancreas group or the IPMN group.

• Pancreatic PDFF may be a potential biomarker for the development of IPMN with a concomitant invasive carcinoma.

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Abbreviations

BMI:

Body mass index

DM:

Diabetes mellitus

FOV:

Field of view

HbA1c:

Hemoglobin A1c

IPMN:

Intraductal papillary mucinous neoplasm

IPMN-IC:

Intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma

PACS:

Picture archiving and communication system

PDAC:

Pancreatic ductal adenocarcinoma

PDFF:

Proton density fat fraction

SIR:

Signal intensity ratio

SIR-I:

Signal intensity ratio in in-phase imaging

SIR-O:

Signal intensity ratio in opposed-phase imaging

SIR-T2:

Signal intensity ratio in T2-weighted imaging

T1WI:

T1-weighted imaging

T2WI:

T2-weighted imaging

TE:

Echo time

TR:

Repetition time

TSE:

Turbo spin echo

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Funding

The authors state that this work has not received any funding.

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Authors and Affiliations

  1. Department of Radiology, Kawasaki Medical School, 577 Matsushima, Kurashiki city, Okayama, 701-0192, Japan

    Hidemitsu Sotozono, Akihiko Kanki, Kazuya Yasokawa, Akira Yamamoto, Hiroyasu Sanai, Kazunori Moriya & Tsutomu Tamada

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  1. Hidemitsu Sotozono
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  2. Akihiko Kanki
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  3. Kazuya Yasokawa
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  4. Akira Yamamoto
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  5. Hiroyasu Sanai
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  6. Kazunori Moriya
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  7. Tsutomu Tamada
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Corresponding author

Correspondence to Hidemitsu Sotozono.

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The scientific guarantor of this publication is Tsutomu Tamada.

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The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

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• performed at one institution

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Sotozono, H., Kanki, A., Yasokawa, K. et al. Value of 3-T MR imaging in intraductal papillary mucinous neoplasm with a concomitant invasive carcinoma. Eur Radiol 32, 8276–8284 (2022). https://doi.org/10.1007/s00330-022-08881-6

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  • DOI: https://doi.org/10.1007/s00330-022-08881-6

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