Abstract
Objectives
Coronary computed tomography angiography (CCTA) has rapidly developed in the coronary artery disease (CAD) field. However, manual coronary artery tree segmentation and reconstruction are time-consuming and tedious. Deep learning algorithms have been successfully developed for medical image analysis to process extensive data. Thus, we aimed to develop a deep learning tool for automatic coronary artery reconstruction and an automated CAD diagnosis model based on a large, single-centre retrospective CCTA cohort.
Methods
Automatic CAD diagnosis consists of two subtasks. One is a segmentation task, which aims to extract the region of interest (ROI) from original images with U-Net. The second task is an identification task, which we implemented using 3DNet. The coronary artery tree images and clinical parameters were input into 3DNet, and the CAD diagnosis result was output.
Results
We built a coronary artery segmentation model based on CCTA images with the corresponding labelling. The segmentation model had a mean Dice value of 0.771 ± 0.021. Based on this model, we built an automated diagnosis model (classification model) for CAD. The average accuracy and area under the receiver operating characteristic curve (AUC) were 0.750 ± 0.056 and 0.737, respectively.
Conclusion
Herein, using a deep learning algorithm, we realized the rapid classification and diagnosis of CAD from CCTA images in two steps. Our deep learning model can automatically segment the coronary artery quickly and accurately and can deliver a diagnosis of ≥ 50% coronary artery stenosis. Artificial intelligence methods such as deep learning have the potential to elevate the efficiency in CCTA image analysis considerably.
Key Points
• The deep learning model rapidly achieved a high Dice value (0.771 ± 0.0210) in the autosegmentation of coronary arteries using CCTA images.
• Based on the segmentation model, we built a CAD autoclassifier with the 3DNet algorithm, which achieved a good diagnostic performance (AUC) of 0.737.
• The deep neural network could be used in the image postprocessing of coronary computed tomography angiography to achieve a quick and accurate diagnosis of CAD.
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Abbreviations
- AUC:
-
Area under the curve
- BP:
-
Backpropagation
- CAD:
-
Coronary artery disease
- CAD-RADS:
-
Coronary Artery Disease Reporting and Data System
- CCTA:
-
Coronary computed tomography angiography
- DSC:
-
Dice similarity coefficient
- PPV:
-
Positive predictive value
- ROI:
-
Region of interest
- SCCT:
-
Society of Cardiovascular Computed Tomography
- SD:
-
Standard deviation
- TPVF:
-
True positive volume fraction
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Funding
Funding of this work was supported by the National Major Science and Technology Projects (grant number 2018AAA0100201) to Z.Y.; the National Natural Science Foundation of China (grant 81970325 to M.C.; grant number 61906127 to J.W.); the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University to M.C.; the Science and Technology Achievement Transformation Fund of West China Hospital of Sichuan University (CGZH19009) to M.C; and Open Fund Research from State Key Laboratory of Hydraulics and Mountain River Engineering (SKHL1920 to Xiong. T.Y.)
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The scientific guarantors of this publication are Prof. Zhang Yi and Prof. Mao Chen.
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No complex statistical methods were necessary for this paper.
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Written informed consent was obtained from all subjects (patients) in this study.
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• retrospective
• diagnostic study
• performed at one institution
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Li, Y., Wu, Y., He, J. et al. Automatic coronary artery segmentation and diagnosis of stenosis by deep learning based on computed tomographic coronary angiography. Eur Radiol 32, 6037–6045 (2022). https://doi.org/10.1007/s00330-022-08761-z
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DOI: https://doi.org/10.1007/s00330-022-08761-z