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Value of high frame rate contrast-enhanced ultrasound in distinguishing gallbladder adenoma from cholesterol polyp lesion

  • Ultrasound
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To compare the diagnostic value of high frame rate contrast-enhanced ultrasound (H-CEUS) in distinguishing gallbladder adenomas from cholesterol polyp lesions with that of CEUS.

Methods

This study enrolled 94 patients with gallbladder polyp lesions (GPLs) who underwent laparoscopic cholecystectomy. CEUS and H-CEUS were performed before surgery. The perfusion features of GPLs and the final diagnosis as determined by both technologies were compared.

Results

There were differences in vascular types between gallbladder adenomas and cholesterol polyp lesions observed on H-CEUS (p < 0.05), while there were no differences in vascular types between gallbladder adenomas and cholesterol polyp lesions observed on CEUS (p > 0.05). In the cholesterol polyp lesion group, there were no differences in vascular types between CEUS and H-CEUS (p > 0.05), while the vascular types were different between CEUS and H-CEUS in the gallbladder adenoma group (p < 0.05). The diagnostic value of H-CEUS in distinguishing gallbladder adenomas from cholesterol polyp lesions was better than that of CEUS.

Conclusions

H-CEUS improved the time resolution by increasing the frame rate, which helped to accurately reflect the difference in the microcirculation of GPLs and improved the ability of a differential diagnosis between cholesterol polyp lesions and adenomas. H-CUES may provide an effective means of imaging for patients with GPLs regarding the choice of treatment options.

Key Points

• High frame rate CEUS improves the time resolution of CEUS by increasing the frame rate.

• High frame rate CEUS is helpful to accurately evaluate the microvascular morphology of a gallbladder polyp lesion in the arterial phase.

• High frame rate CEUS helps patients with gallbladder polyp lesions to choose the appropriate treatment means.

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Abbreviations

CDFI:

Color Doppler flow imaging

CEUS:

Contrast-enhanced ultrasound

FOV:

Field-of-view

GPLs:

Gallbladder polyp lesions

H-CEUS:

High frame rate contrast-enhanced ultrasound

NPV:

Negative predictive value

PPV:

Positive predictive value

US:

Ultrasound

ZST+:

Zone Sonography Technology plus

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Funding

The authors state that this work has not received any funding.

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Author notes

  1. Xiang Fei and Nan Li contributed equally to this work.

Authors and Affiliations

  1. Department of Ultrasound, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China

    Xiang Fei, Nan Li, Lianhua Zhu, Peng Han, Bo Jiang & Yukun Luo

  2. Department of Hepatobiliary Surgery, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China

    Wenbo Tang

  3. Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Nanshan District, Shenzhen, 518055, China

    Maodong Sang & Xirui Zhang

Authors
  1. Xiang Fei
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  2. Nan Li
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  4. Peng Han
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Correspondence to Yukun Luo.

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The scientific guarantor of this publication is Yukun Luo.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

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Written informed consent was obtained from all subjects (patients) in this study.

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• Retrospective

• Cross-sectional study

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Fei, X., Li, N., Zhu, L. et al. Value of high frame rate contrast-enhanced ultrasound in distinguishing gallbladder adenoma from cholesterol polyp lesion. Eur Radiol 31, 6717–6725 (2021). https://doi.org/10.1007/s00330-021-07730-2

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  • DOI: https://doi.org/10.1007/s00330-021-07730-2

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