Skip to main content
SpringerLink
Log in

Postprandial changes in secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP with a spatially selective inversion-recovery (IR) pulse

  • Hepatobiliary-Pancreas
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the influence of oral ingestion on the secretory flow dynamics of physiological pancreatic juice within the main pancreatic duct in healthy subjects by using cine-dynamic MRCP with spatially-selective inversion-recovery (IR) pulse non-invasively.

Materials and methods

Thirty-eight healthy subjects were investigated. MRCP with spatially-selective IR pulse was repeated every 15 s for 5 min to acquire a total of 20 images (cine-dynamic MRCP). A set of 20 MRCP images was repeatedly obtained before and after liquid oral ingestion every 7 min (including 2-min interval) for 40 min (a total of seven sets). Secretion grade of pancreatic juice on cine-dynamic MRCP was compared before and after oral ingestion using the nonparametric Wilcoxon signed-rank test.

Results

Median secretion grades of pancreatic juice at 5 min (score = 2.15), 12 min (score = 1.95) and 19 min (score = 2.05) after ingestion were significantly higher than that before ingestion (score = 1.40) (P = 0.004, P = 0.032, P = 0.045, respectively). Secretion grade of pancreatic juice showed a maximum peak of 2.15 at 5 min after ingestion. Thereafter, the secretion grade of pancreatic juice tended to gradually decline.

Conclusion

Non-invasive cine-dynamic MRCP using spatially-selective IR pulse showed potential for evaluating postprandial changes in the secretory flow dynamics of pancreatic juice as a physiological reaction.

Key Points

• Secretion grade of pancreatic juice at cine-dynamic MRCP after ingestion was evaluated.

• Secretion grade was significantly increased within 19 min after liquid meal ingestion.

• Secretion grade showed maximum peak of 2.15 at 5 min after ingestion.

• Postprandial changes in pancreatic juice flow can be assessed by cine-dynamic MRCP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Becker HD, Werner M, Schafmayer A (1984) Release of radioimmunologic cholecystokinin in human subjects. Am J Surg 147(1):124–129

    Article  CAS  PubMed  Google Scholar 

  2. Katada N, Noda A, Hayakawa T (1983) Postprandial pancreatic secretion and plasma hormones in dogs with pancreatic fistula. Am J Gastroenterol 78(11):740–744

    CAS  PubMed  Google Scholar 

  3. Brunner H, Northfield TC, Hofmann AF, Go VL, Summerskill WH (1974) Gastric emptying and secretion of bile acids, cholesterol, and pancreatic enzymes during digestion. Duodenal perfusion studies in healthy subjects. Mayo Clin Proc 49(11):851–860

    CAS  PubMed  Google Scholar 

  4. Malagelada JR, Go VL, Summerskill WH (1979) Different gastric, pancreatic, and biliary responses to solid–liquid or homogenized meals. Dig Dis Sci 24(2):101–110

    Article  CAS  PubMed  Google Scholar 

  5. Beglinger C, Fried M, Whitehouse I, Jansen JB, Lamers CB, Gyr K (1985) Pancreatic enzyme response to a liquid meal and to hormonal stimulation. Correlation with plasma secretin and cholecystokinin levels. J Clin Invest 75(5):1471–1476

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hayakawa T, Katada N, Kondo T, Shibata T, Kodaira T, Ikei N, Hamaoka T (1988) Meal-stimulated cholecystokinin release and exocrine pancreatic secretion in dogs. Research in experimental medicine. Z Gesamte Exp Med Einschliesslich Exp Chir 188(1):19–25

    CAS  Google Scholar 

  7. Gullo L, Priori P, Pezzilli R, Biliotti G, Mattioli G, Barbara L (1988) Pancreatic secretory response to ordinary meals: studies with pure pancreatic juice. Gastroenterology 94(2):428–433

    Article  CAS  PubMed  Google Scholar 

  8. Ito K, Torigoe T, Tamada T, Yoshida K, Murakami K, Yoshimura M (2011) The secretory flow of pancreatic juice in the main pancreatic duct: visualization by means of MRCP with spatially selective inversion-recovery pulse. Radiology 261:582–586

    Article  PubMed  Google Scholar 

  9. Torigoe T, Ito K, Yamamoto A, Kanki A, Yasokawa K, Tamada T, Yoshida K (2014) Age-related change of the secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP using spatially selective inversion recovery pulse. AJR Am J Roentgenol 202(5):1022–1026

    Article  PubMed  Google Scholar 

  10. Johansson C, Lagerlof HO, Ekelund K, Kulsdom N, Larsson I, Nylind B (1972) Studies of gastrointestinal interactions. 3. Determination of gastric secretion and evacuation, biliary and pancreactic secretion, intestinal absorption, intestinal transit time and flow of water in man. Scand J Gastroenterol 7(5):489–499

    Article  CAS  PubMed  Google Scholar 

  11. Gullo L, Priori P, Costa PL, Mattioli G, Labo G (1984) Action of secretin on pancreatic enzyme secretion in man. Studies on pure pancreatic juice. Gut 25(8):867–873

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Tiscornia OM, Cresta MA, Celener D, Negri G, Vaccaro MI, Waisman H, Bustos Fernandez L, Dreiling DA (1988) Pure pancreatic juice in humans: orange-lemon-juice-induced secretory effects. Comparative analysis with a regular meal, sorbitol, acidified peptone broth and secretin. Int J Pancreatol Off J Int Assoc Pancreatol 3(6):469–476

    CAS  Google Scholar 

  13. Chang CA, McKenna RD, Beck IT (1968) Gastric emptying rate of the water and fat phases of a mixed test meal in man. Gut 9(4):420–424

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Meyer JH, MacGregor IL, Gueller R, Martin P, Cavalieri R (1976) 99mTc-tagged chicken liver as a marker of solid food in the human stomach. Am J Dig Dis 21(4):296–304

    Article  CAS  PubMed  Google Scholar 

  15. Malagelada JR (1977) Quantificantion of gastric solid–liquid discrimination during digestion of ordinary meals. Gastroenterology 72(6):1264–1267

    CAS  PubMed  Google Scholar 

  16. Malagelada JR, Longstreth GF, Summerskill WH, Go VL (1976) Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterology 70(2):203–210

    CAS  PubMed  Google Scholar 

  17. Bolondi L, Bortolotti M, Santi V, Calletti T, Gaiani S, Labo G (1985) Measurement of gastric emptying time by real-time ultrasonography. Gastroenterology 89(4):752–759

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The scientific guarantor of this publication is Katsuyoshi Ito. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding.

No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. No study subjects or cohorts have been previously reported. Methodology: prospective, diagnostic or prognostic study, performed at one institution.

Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan

    Kazuya Yasokawa, Katsuyoshi Ito, Tsutomu Tamada, Akira Yamamoto, Minoru Hayashida, Teruyuki Torigoe, Daigo Tanimoto, Atsushi Higaki, Yasufumi Noda & Ayumu Kido

Authors
  1. Kazuya Yasokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katsuyoshi Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tsutomu Tamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Akira Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Minoru Hayashida
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Teruyuki Torigoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Daigo Tanimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Atsushi Higaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yasufumi Noda
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ayumu Kido
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kazuya Yasokawa.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yasokawa, K., Ito, K., Tamada, T. et al. Postprandial changes in secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP with a spatially selective inversion-recovery (IR) pulse. Eur Radiol 26, 4339–4344 (2016). https://doi.org/10.1007/s00330-016-4287-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-016-4287-5

Keywords

Search

Navigation