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Imaging of the entire cerebrospinal fluid volume with a multistation 3D SPACE MR sequence: feasibility study in patients with hydrocephalus

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Abstract

Objectives

To evaluate the feasibility of imaging the entire cerebrospinal fluid (CSF) volume using the SPACE MR sequence.

Methods

The SPACE sequence encompassing the brain and spine was performed at 1.5 T in 12 healthy volunteers and 26 consecutive patients with hydrocephalus. Image contrast was estimated using difference ratios in signal intensity between CSF and its background. Segmentation of CSF was performed using geometrical features and a topological assumption of CSF shapes. Subarachnoid and ventricular CSF space volumes were assessed in volunteers and patients and linear discriminant analysis was performed.

Results

Image contrast was 0.94 between the CSF and the brain and 0.90 between the CSF and the spinal cord. According to the phantom study, the accuracy of CSF volume measurement was 98.5 %. A clear distinction between patients and healthy volunteers was obtained using the linear discriminant analysis. Significant linear regression was found in healthy volunteers between ventricular (Vv) and the whole subarachnoid CSF volume (Vs) with Vv = 0.083 Vs.

Conclusions

Imaging of the entire CSF volume is feasible in healthy volunteers and patients with hydrocephalus. CSF volume can be obtained on a whole-body scale. This approach may be of use for the diagnosis and follow-up of patients with hydrocephalus.

Key Points

• MRI assessment of CSF volume is feasible in healthy volunteers/hydrocephalus patients.

• CSF volume can be obtained on a whole-body scale.

• The ratio of subarachnoid and ventricular CSF is constant in healthy volunteers.

• CSF linear discriminant analysis can distinguish between patients and healthy volunteers.

• Entire CSF volume imaging is useful for diagnosing and following hydrocephalus.

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Abbreviations

CSF:

Cerebrospinal fluid

NCH:

Non-communicating hydrocephalus

CH:

Communicating hydrocephalus

SPACE:

Sampling perfection with application optimised contrast using different flip-angle evolution

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Acknowledgements

The authors thank Iwona M’Kenzie Hall for her editorial assistance.

Alexandre Vignaud is an employee of Siemens.

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Authors and Affiliations

  1. Department of Neuroradiology, Hôpital Henri Mondor, Créteil, France

    Jérôme Hodel

  2. Department of Neuroradiology, Hôpital Roger Salengro, Lille, France

    Jérôme Hodel & Xavier Leclerc

  3. Department of Radiology, Hôpital Saint Joseph, 185, Rue Raymond Losserand, Paris, France

    Jérôme Hodel & Marc Zins

  4. Laboratoire Images Signaux et Systèmes Intelligents, Université Paris XII, Créteil, France

    Alain Lebret & Eric Petit

  5. Siemens Healthcare, Saint Denis, France

    Alexandre Vignaud

  6. Department of Neurosurgery, Hôpital Henri Mondor, Créteil, France

    Philippe Decq

  7. Department of Radiology, Hôpital Henri Mondor, Créteil, France

    Alain Rahmouni

Authors
  1. Jérôme Hodel
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  2. Alain Lebret
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  3. Eric Petit
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  4. Xavier Leclerc
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  6. Alexandre Vignaud
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  7. Philippe Decq
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  8. Alain Rahmouni
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Correspondence to Jérôme Hodel.

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Hodel, J., Lebret, A., Petit, E. et al. Imaging of the entire cerebrospinal fluid volume with a multistation 3D SPACE MR sequence: feasibility study in patients with hydrocephalus. Eur Radiol 23, 1450–1458 (2013). https://doi.org/10.1007/s00330-012-2732-7

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  • DOI: https://doi.org/10.1007/s00330-012-2732-7

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