Abstract
Objective
To investigate the contribution of contrast-enhanced MR-colonography (CE-MR-C) for the diagnosis of intestinal endometriosis.
Methods
One hundred and four women with suspected endometriosis were prospectively enrolled. All patients were subjected to MRI consisting of two phases: pelvic high-resolution MRI (HR-MRI) followed by CE-MR-C after colonic distension using a 1.5-liter water enema and injection of 0.15 ml/kg of 0.5 M gadolinium-DTPA with T1w high-resolution isotropic volume (THRIVE) and balanced turbo field echo (BTFE) images. HR-MRI and CE-MR-C were considered as two datasets, which were independently reviewed by two radiologists with 12 and 2 years’ experience respectively. The presence of deep pelvic endometriotic lesions with particular attention to colorectal involvement was recorded.
Results
MRI findings correlated with laparoscopy in all cases. Thanks to CE-MR-C images, sensitivity, specificity, PPV, NPV and accuracy for diagnosis of colorectal endometriosis increased from 76%, 96%, 84%, 93% and 91%, to 95%, 97%, 91%, 99% and 97% for the most experienced radiologist and from 62%, 93%, 72%, 89% and 85%, to 86%, 94%, 82%, 96% and 92% for the less experienced radiologist; moreover, the interobserver agreement increased from 0.63 to 0.80 (Cohen’s K test).
Conclusion
CE-MR-C allows easier recognition of colorectal endometriosis and higher interobserver agreement.
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References
Vigano P, Parazzini F, Somigliana E, Vercellini P (2004) Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol 18:177–200
Schindler AE (2004) Pathophysiology, diagnosis and treatment of endometriosis. Minerva Ginecol 56:419–435
Koninckx PR, Meuleman C, Demeyere S, Lesaffre E, Cornillie FJ (1991) Suggestive evidence that pelvic endometriosis is a progressive disease, whereas deeply infiltrating endometriosis is associated with pelvic pain. Fertil Steril 55:759–765
Remorgida V, Ferrero S, Fulcheri E, Ragni N, Martin DC (2007) Bowel endometriosis: presentation, diagnosis, and treatment. Obstet Gynecol Surv 62:461–470
Redwine DB (1999) Ovarian endometriosis: a marker for more extensive pelvic and intestinal disease. Fertil Steril 72:310–315
Keckstein J, Wiesinger H (2005) Deep endometriosis, including intestinal involvement—the interdisciplinary approach. Minim Invasive Ther Allied Technol 14:160–166
Kennedy S, Hadfield R, Barlow D, Weeks DE, Laird E, Golding S (1997) Use of MRI in genetic studies of endometriosis. Am J Med Genet 71:371–372
Landi S, Barbieri F, Fiaccavento A et al (2004) Preoperative double-contrast barium enema in patients with suspected intestinal endometriosis. J Am Assoc Gynecol Laparosc 11:223–228
Abrao MS, Goncalves MO, Dias JA Jr, Podgaec S, Chamie LP, Blasbalg R (2007) Comparison between clinical examination, transvaginal sonography and magnetic resonance imaging for the diagnosis of deep endometriosis. Hum Reprod 22:3092–3097
Ribeiro HS, Ribeiro PA, Rossini L, Rodrigues FC, Donadio N, Aoki T (2008) Double-contrast barium enema and transrectal endoscopic ultrasonography in the diagnosis of intestinal deeply infiltrating endometriosis. J Minim Invasive Gynecol 15:315–320
Piketty M, Chopin N, Dousset B et al (2009) Preoperative work-up for patients with deeply infiltrating endometriosis: transvaginal ultrasonography must definitely be the first-line imaging examination. Hum Reprod 24:602–607
Chamie LP, Pereira RM, Zanatta A, Serafini PC (2010) Transvaginal US after bowel preparation for deeply infiltrating endometriosis: protocol, imaging appearances, and laparoscopic correlation. Radiographics 30:1235–1249
Bazot M, Bornier C, Dubernard G, Roseau G, Cortez A, Darai E (2007) Accuracy of magnetic resonance imaging and rectal endoscopic sonography for the prediction of location of deep pelvic endometriosis. Hum Reprod 22:1457–1463
Dumontier I, Roseau G, Vincent B et al (2000) Comparison of endoscopic ultrasound and magnetic resonance imaging in severe pelvic endometriosis. Gastroenterol Clin Biol 24:1197–1204
Roseau G, Dumontier I, Palazzo L et al (2000) Rectosigmoid endometriosis: endoscopic ultrasound features and clinical implications. Endoscopy 32:525–530
Delpy R, Barthet M, Gasmi M et al (2005) Value of endorectal ultrasonography for diagnosing rectovaginal septal endometriosis infiltrating the rectum. Endoscopy 37:357–361
Faccioli N, Foti G, Manfredi R et al (2010) Evaluation of colonic involvement in endometriosis: double-contrast barium enema vs. magnetic resonance imaging. Abdom Imaging 35:414–421
Faccioli N, Manfredi R, Mainardi P et al (2008) Barium enema evaluation of colonic involvement in endometriosis. AJR Am J Roentgenol 190:1050–1054
Biscaldi E, Ferrero S, Fulcheri E, Ragni N, Remorgida V, Rollandi GA (2007) Multislice CT enteroclysis in the diagnosis of bowel endometriosis. Eur Radiol 17:211–219
Biscaldi E, Ferrero S, Remorgida V, Rollandi GA (2007) Bowel endometriosis: CT-enteroclysis. Abdom Imaging 32:441–450
Roy C, Balzan C, Thoma V, Sauer B, Wattiez A, Leroy J (2009) Efficiency of MR imaging to orientate surgical treatment of posterior deep pelvic endometriosis. Abdom Imaging 34:251–259
Chamie LP, Blasbalg R, Goncalves MO, Carvalho FM, Abrao MS, de Oliveira IS (2009) Accuracy of magnetic resonance imaging for diagnosis and preoperative assessment of deeply infiltrating endometriosis. Int J Gynaecol Obstet 106:198–201
Scarmato VJ, Levine MS, Herlinger H, Wickstrom M, Furth EE, Tureck RW (2000) Ileal endometriosis: radiographic findings in five cases. Radiology 214:509–512
Fedele L, Bianchi S, Zanconato G, Berlanda N, Borruto F, Frontino G (2005) Tailoring radicality in demolitive surgery for deeply infiltrating endometriosis. Am J Obstet Gynecol 193:114–117
Fedele L, Bianchi S, Zanconato G, Bettoni G, Gotsch F (2004) Long-term follow-up after conservative surgery for rectovaginal endometriosis. Am J Obstet Gynecol 190:1020–1024
Stepniewska A, Pomini P, Scioscia M, Mereu L, Ruffo G, Minelli L (2010) Fertility and clinical outcome after bowel resection in infertile women with endometriosis. Reprod Biomed Online 20:602–609
Darai E, Bazot M, Rouzier R, Houry S, Dubernard G (2007) Outcome of laparoscopic colorectal resection for endometriosis. Curr Opin Obstet Gynecol 19:308–313
Zanardi R, Del Frate C, Zuiani C, Del Frate G, Bazzocchi M (2003) Staging of pelvic endometriosis using magnetic resonance imaging compared with the laparoscopic classification of the American Fertility Society: a prospective study. Radiol Med 105:326–338
Del Frate C, Girometti R, Pittino M, Del Frate G, Bazzocchi M, Zuiani C (2006) Deep retroperitoneal pelvic endometriosis: MR imaging appearance with laparoscopic correlation. Radiographics 26:1705–1718
Chapron C, Vieira M, Chopin N et al (2004) Accuracy of rectal endoscopic ultrasonography and magnetic resonance imaging in the diagnosis of rectal involvement for patients presenting with deeply infiltrating endometriosis. Ultrasound Obstet Gynecol 24:175–179
Bazot M, Darai E, Hourani R et al (2004) Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease. Radiology 232:379–389
Chassang M, Novellas S, Bloch-Marcotte C et al (2009) Utility of vaginal and rectal contrast medium in MRI for the detection of deep pelvic endometriosis. Eur Radiol
Hartmann D, Bassler B, Schilling D et al (2006) Colorectal polyps: detection with dark-lumen MR colonography versus conventional colonoscopy. Radiology 238:143–149
Zijta FM, Bipat S, Stoker J (2010) Magnetic resonance (MR) colonography in the detection of colorectal lesions: a systematic review of prospective studies. Eur Radiol 20:1031–1046
Achiam MP, Logager VB, Chabanova E, Eegholm B, Thomsen HS, Rosenberg J (2009) Diagnostic accuracy of MR colonography with fecal tagging. Abdom Imaging 34:483–490
Acknowledgements
The authors wish to thank Ms. Paulene Butts for preparing the English version of the manuscript, Dr. Domenico Piscitelli, Department of Pathology of the University Hospital “Policlinico” of Bari (Italy) for furnishing figures 1-f and 6-f and Salvatore De Ceglie, radiological technologist, for carrying out MR examinations.
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Scardapane, A., Bettocchi, S., Lorusso, F. et al. Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography. Eur Radiol 21, 1553–1563 (2011). https://doi.org/10.1007/s00330-011-2079-5
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DOI: https://doi.org/10.1007/s00330-011-2079-5