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Image fusion of coronary CT angiography and cardiac perfusion MRI: a pilot study

  • Cardiac
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Abstract

Objective

To develop a tool for the image fusion of computed tomography coronary angiography (CTCA) and cardiac magnetic resonance imaging (CMR).

Methods

Surface representations and volume-rendered images from fused CTCA/CMR data of five patients with significant coronary artery disease (CAD) on CTCA and perfusion deficits on CMR were generated using a newly developed software prototype. The spatial relationship of significant coronary artery stenosis at CTCA and myocardial defects at CMR was evaluated.

Results

Registration of CTCA and CMR images was possible in all patients. The comprehensive three-dimensional visualisation of fused CTCA and CMR data accurately demonstrated the relationship between coronary artery stenoses and myocardial defects in all patients.

Conclusion

The introduced tool enables image fusion of CTCA and CMR data sets and allows for correct superposition of the coronary arteries derived from CTCA onto the corresponding myocardial segments derived from CMR. The method facilitates the comprehensive assessment of the functionally relevant CAD by the exact allocation of culprit coronary stenoses to corresponding myocardial defects at a low radiation dose.

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Acknowledgements

This study was supported by the National Center of Competence in Research, Computer Aided and Image Guided Medical Interventions of the Swiss National Science Foundation.

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Authors and Affiliations

  1. Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland

    Paul Stolzmann, Hatem Alkadhi, Hans Scheffel, Stephan Baumueller, Borut Marincek & Olivio F. Donati

  2. Cardiac MR PET CT Program, Massachusetts General Hospital, 165 Cambridge Street, Suite 400, Boston, MA, 02114, USA

    Hatem Alkadhi

  3. Fraunhofer MEVIS, Bremen, Germany

    Anja Hennemuth & Caroline Kuehnel

  4. Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

    Sebastian Kozerke

  5. Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland

    Volkmar Falk

Authors
  1. Paul Stolzmann
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  2. Hatem Alkadhi
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  3. Hans Scheffel
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  4. Anja Hennemuth
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  5. Caroline Kuehnel
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  6. Stephan Baumueller
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  7. Sebastian Kozerke
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  8. Volkmar Falk
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  9. Borut Marincek
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  10. Olivio F. Donati
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Corresponding author

Correspondence to Hatem Alkadhi.

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Stolzmann, P., Alkadhi, H., Scheffel, H. et al. Image fusion of coronary CT angiography and cardiac perfusion MRI: a pilot study. Eur Radiol 20, 1174–1179 (2010). https://doi.org/10.1007/s00330-010-1746-2

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  • DOI: https://doi.org/10.1007/s00330-010-1746-2

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