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Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia

  • Magnetic Resonance
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Abstract

Objective

To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand.

Methods

A group of 27 mongrel dogs were divided into 10 controls and 17 with acute coronary stenosis. On 1.5-T MRI, first-pass perfusion imaging with a bolus injection of a blood-pool contrast agent was performed to determine myocardial perfusion both at rest and during either dipyridamole-induced vasodilation or dobutamine-induced stress. Regional values of MBF and MBV were quantified by using a fast mapping technique. Color microspheres and 99mTc-labeled red blood cells were injected to obtain respective gold standards.

Results

Microsphere-measured MBF and 99mTc-measured MBV reference values correlated well with the MR results. Given the same changes in MBF, changes in MBV are twofold greater with dobutamine than with dipyridamole. Under dobutamine stress, MBV shows better association with total myocardial oxygen demand than MBF. Coronary stenosis progressively reduced this association in the presence of increased stenosis severity.

Conclusions

MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion.

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Acknowledgements

This work was supported by a grant from the National Institutes of Health R01 HL74019-01

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Authors and Affiliations

  1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA

    Kyle S. McCommis, Thomas A. Goldstein, Thomas Pilgram, Robert J. Gropler & Jie Zheng

  2. Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA

    Dana R. Abendschein & Robert J. Gropler

  3. Bayer Schering Pharma AG, Berlin, Germany

    Bernd Misselwitz

  4. Cardiovascular Imaging Lab, 510 South Kingshighway Blvd., Campus Box 8225, St. Louis, MO, 63110, USA

    Jie Zheng

Authors
  1. Kyle S. McCommis
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  2. Thomas A. Goldstein
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  3. Dana R. Abendschein
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  4. Bernd Misselwitz
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  5. Thomas Pilgram
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  6. Robert J. Gropler
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  7. Jie Zheng
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Corresponding author

Correspondence to Jie Zheng.

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McCommis, K.S., Goldstein, T.A., Abendschein, D.R. et al. Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia. Eur Radiol 20, 2005–2012 (2010). https://doi.org/10.1007/s00330-010-1740-8

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  • DOI: https://doi.org/10.1007/s00330-010-1740-8

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