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Sensitivity and specificity of unenhanced MR mammography (DWI combined with T2-weighted TSE imaging, ueMRM) for the differentiation of mass lesions

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Abstract

Objective

This study was performed to assess the sensitivity and specificity for malignant and benign mass lesions of a diagnostic approach combining DWI with T2-weighted images (unenhanced MR mammography, ueMRM) and compare the results with contrast-enhanced MR mammography (ceMRM).

Materials and methods

Consecutive patients undergoing histopathological verification of mass lesions after MR mammography without prior breast interventions (contrast-enhanced T1-weighted, T2-weighted and DWI sequences) were eligible for this retrospective investigation. Two blinded observers first rated ueMRM and then ceMRM according to the BIRADS scale. Lesion size, ADC values and T2-weighted TSE descriptors were assessed.

Results

This study examined 81 lesions (27 benign, 54 malignant). Sensitivity of ueMRM was 93% (observer 1) and 86% (observer 2), respectively. Sensitivity of ceMRM was 96.5% (observer 1) and 98.3% (observer 2). Specificity was 85.2% (ueMRM) and 92.6% (ceMRM) for both observers. The differences between both methods and observers were not significant (P ≥ 0.09). Lesion size measurements did not differ significantly among all sequences analyzed. Tumor visibility was worse using ueMRM for both benign (P < 0.001) and malignant lesions (P = 0.004).

Conclusion

Sensitivity and specificity of ueMRM in mass lesions equal that of ceMRM. However, a reduced lesion visibility in ueMRM may lead to more false-negative findings.

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Authors and Affiliations

  1. Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07740, Jena, Germany

    Pascal A. T. Baltzer, Matthias Benndorf, Matthias Dietzel & Werner A. Kaiser

  2. Institute of Pathology, Friedrich Schiller University Jena, Ziegmühlenweg 1, 07740, Jena, Germany

    Mieczyslaw Gajda

  3. Clinic of Gynecology, Friedrich Schiller University Jena, Bachstr. 18, 07740, Jena, Germany

    Oumar Camara

Authors
  1. Pascal A. T. Baltzer
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  2. Matthias Benndorf
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  3. Matthias Dietzel
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  4. Mieczyslaw Gajda
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  5. Oumar Camara
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  6. Werner A. Kaiser
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Correspondence to Pascal A. T. Baltzer.

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Baltzer, P.A.T., Benndorf, M., Dietzel, M. et al. Sensitivity and specificity of unenhanced MR mammography (DWI combined with T2-weighted TSE imaging, ueMRM) for the differentiation of mass lesions. Eur Radiol 20, 1101–1110 (2010). https://doi.org/10.1007/s00330-009-1654-5

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  • DOI: https://doi.org/10.1007/s00330-009-1654-5

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