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Comparison of STIR turbo SE imaging and diffusion-weighted imaging of the lung: capability for detection and subtype classification of pulmonary adenocarcinomas

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Abstract

Objective

The aim of the study was to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) for detection and subtype classification in pulmonary adenocarcinomas through comparison with short TI inversion recovery turbo spin-echo imaging sequence (STIR).

Methods

Thirty-two patients (mean age, 65.2 years) with 33 adenocarcinomas (mean diameter, 27.6 mm) were enrolled in this study. The detection rates of both sequences were compared. The ADC values on DWI and the contrast ratio (CR) between cancer and muscle on STIR were measured and those were compared across subtype classifications. Finally, ROC-based positive tests were performed to differentiate subtype classifications, and differentiation capabilities were compared.

Results

The DWI detection rate [85% (28/33)] was significantly lower than that of STIR [100% (33/33), P < 0.05]. The ADC values showed no significant difference regarding subtype classification; however, the CRs of bronchio-alveolar carcinomas (BACs) were significantly lower than those of other types (P < 0.05). When threshold values for differentiating BACs from others were adapted, the sensitivity and accuracy of DWI were significantly lower than those of STIR (P < 0.05). For differentiating adenocarcinomas with mixed subtypes from those with no BA component, there were no significant differences between the two sequences.

Conclusion

STIR is more sensitive for detection and subtype classification than DWI.

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Acknowledgements

Yoshikazu Kotani, M.D. and Yoshihiro Nishimura, M.D., Ph.D. (Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine); Yoshimasa Maniwa, M.D., Ph.D. (Division of Pulmonary Surgery, Hyogo Cancer Center); Hideaki Kawamitsu, B.S. (Division of Radiology, Kobe University Hospital) and Masahiko Fujii, M.D. (Department of Radiology, Kobe University Graduate School of Medicine) are acknowledged for their contribution to this work. This work was supported by Eizai and Philips Medical Systems.

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Authors and Affiliations

  1. Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Hisanobu Koyama, Yoshiharu Ohno, Yumiko Onishi, Keiko Matsumoto, Munenobu Nogami, Daisuke Takenaka & Kazuro Sugimura

  2. Division of Radiology, Kobe University Hospital, Kobe, Japan

    Nobukazu Aoyama

  3. Division of Cardiovascular, Thoracic and Pediatric Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Wataru Nishio

  4. Division of Pathology, Hyogo Cancer Center, Akashi, Japan

    Chiho Ohbayashi

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  1. Hisanobu Koyama
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Correspondence to Hisanobu Koyama.

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Koyama, H., Ohno, Y., Aoyama, N. et al. Comparison of STIR turbo SE imaging and diffusion-weighted imaging of the lung: capability for detection and subtype classification of pulmonary adenocarcinomas. Eur Radiol 20, 790–800 (2010). https://doi.org/10.1007/s00330-009-1615-z

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  • DOI: https://doi.org/10.1007/s00330-009-1615-z

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