Abstract
Objective
To investigate the feasibility and clinical efficacy of ultrasound (US)-guided diffused optical tomography (DOT) in differentiating malignant breast lesions from benign lesions.
Material and methods
From October 2007 to August 2008, 198 women with 214 lesions scheduled for open biopsy were included in this study. Conventional US was used to locate the breast lesion, and DOT to measure the total haemoglobin concentration (THC) for each breast lesion. Sensitivity, specificity and overall accuracy were determined with surgical pathology as the gold standard.
Results
There were 96 benign lesions and 118 malignant lesions. The total haemoglobin concentration (THC) of all 214 lesions was calculated from DOT. The average THC in benign lesions was 125.5 ± 83.4 µmol/L, and in malignant lesions 222.2 ± 87.2 µmol/L. The THC of malignant lesions was significantly higher than that of benign lesions (p < 0.05). When a THC of 140 µmol/L was used as the cutoff value for differentiating breast cancer from benign lesions, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of DOT were 83.9%, 66.7%, 76.2%, 75.6% and 77.1%, respectively. Our study demonstrated that THC was significantly higher in malignant lesions than in benign lesions.
Conclusion
US-guided diffused optical tomography, a noninvasive functional imaging technique, has potential utility in differentiating breast cancer from benign lesions.
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The research was supported by the National Natural Sciences Foundation of China (30570529).
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You, SS., Jiang, YX., Zhu, QL. et al. US-guided diffused optical tomography: a promising functional imaging technique in breast lesions. Eur Radiol 20, 309–317 (2010). https://doi.org/10.1007/s00330-009-1551-y
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DOI: https://doi.org/10.1007/s00330-009-1551-y