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Dynamic contrast-enhanced and diffusion-weighted MRI for early detection of tumoral changes in single-dose and fractionated radiotherapy: evaluation in a rat rhabdomyosarcoma model

  • Magnetic Resonance
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Abstract

We aimed to examine different intratumoral changes after single-dose and fractionated radiotherapy, using diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI in a rat rhabdomyosarcoma model. Four WAG/Rij rats with rhabdomyosarcomas in the flanks received single-dose radiotherapy of 8 Gy, and four others underwent fractionated radiotherapy (five times 3 Gy). In rats receiving single-dose radiotherapy, a significant perfusion decrease was found in the first 2 days post-treatment, with slow recuperation afterwards. No substantial diffusion changes could be seen; tumor growth delay was 12 days. The rats undergoing fractionated radiotherapy showed a similar perfusion decrease early after the treatment. However, a very strong increase in apparent diffusion coefficient occurred in the first 10 days; growth delay was 18 days. DW-MRI and DCE-MRI can be used to show early tumoral changes induced by radiotherapy. Single-dose and fractionated radiotherapy induce an immediate perfusion effect, while the latter induces more intratumoral necrosis.

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Acknowledgments

This work has been partly financially supported by the research grant “Prof. Em. A. L. Baert, Siemens Medical Solutions”.

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Authors and Affiliations

  1. Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    F. De Keyzer, V. Vandecaveye, F. Chen, Y. Ni, G. Marchal, R. Hermans & H. Bosmans

  2. Institute of Diagnostic, Interventional and Pediatric Radiology, University and Inselspital, Bern, Switzerland

    H. Thoeny

  3. Department of Radiotherapy, University Hospitals Leuven, Leuven, Belgium

    S. Nuyts

  4. Lab Experimental Radiotherapy, Catholic University of Leuven (KUL), Leuven, Belgium

    W. Landuyt

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  1. F. De Keyzer
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  2. V. Vandecaveye
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  3. H. Thoeny
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  4. F. Chen
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  5. Y. Ni
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  6. G. Marchal
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  7. R. Hermans
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  8. S. Nuyts
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  9. W. Landuyt
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  10. H. Bosmans
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Correspondence to F. De Keyzer.

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De Keyzer, F., Vandecaveye, V., Thoeny, H. et al. Dynamic contrast-enhanced and diffusion-weighted MRI for early detection of tumoral changes in single-dose and fractionated radiotherapy: evaluation in a rat rhabdomyosarcoma model. Eur Radiol 19, 2663–2671 (2009). https://doi.org/10.1007/s00330-009-1451-1

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  • DOI: https://doi.org/10.1007/s00330-009-1451-1

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