Abstract
The purpose was to evaluate the accuracy of multidetector CT (MDCT) on a 16-row CT scanner in local staging of endometrial carcinoma and more specifically in the assessment of the depth of myometrial invasion and presence of cervical infiltration. This prospective study includes 21 women with newly diagnosed endometrial carcinoma. All CT examinations were performed on a 16-row CT scanner, and the protocol included scanning of the abdomen after intravenous administration of iodinated contrast material, during the portal phase, using a detector collimation of 16×0.75 mm and a pitch of 1.2. Sagittal, parasagittal and oblique reformatted images were evaluated for the depth of myometrial invasion, whether superficial or deep, and the presence of cervical infiltration. Imaging findings were correlated with the histopathologic results. The sensitivity, specificity and accuracy of MDCT in evaluating myometrial invasion were 100%, 80% and 95%, respectively, and for assessing cervical infiltration were 78%, 83% and 81%, respectively. In conclusion, MDCT on a 16-row CT scanner proved accurate in local staging of endometrial carcinoma.
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References
American Cancer Society. Cancer Facts & Figures 2007. Available at: http://www.cancer.org/downloads/STT/CAFF2007f4PWSecured.pdf
Rose PG (1996) Endometrial carcinoma. N Engl J Med 335(9):640–649
Manfredi R, Mirk P, Maresca G, Testa A, Zannoni GF, Giordano D, Scambia G, Marano P (2004) Local-regional staging of endometrial carcinoma: Role of MR imaging in surgical planning. Radiology 231:372–378
Childers JM, Brzechffa RP, Hatch KD, Surwit EA (1993) Laparoscopically assisted surgical staging (LASS) of endometrial cancer. Gynecol Oncol 51:33–38
Kinkel K, Kaji Y, Yu KK, Segal MR, Lu Y, Powell CB, Hricak H (1999). Radiologic staging in patients with endometrial cancer: a meta-analysis. Radiology 212:711–718
Manfredi R, Gui B, Maresca G, Fanfani F, Bonomo L (2005) Endometrial cancer: magnetic resonance imaging. Abdom Imaging 30:626–636
Frei KA, Kinkel K (2001) Staging endometrial cancer: Role of magnetic resonance imaging. J Magn Reson Imaging 13(6):850–855
Ascher SM, Reinhold C (2002) Imaging of cancer of the endometrium. Radiol Clin North Am 40(3):563–576
Seki H, Kimura M, Sakai K (1997). Myometrial invasion of endometrial carcinoma: assessment with dynamic MR and contrast-enhanced T1-weighted images. Clin Radiol 52(1):18–23
Messiou C, Spencer JA, Swift SE (2006) MR staging of endometrial carcinoma. Clin Radiol 61(10):822–832
Hardesty LA, Sumkin JH, Hakim C, Johns C, Nath M (2001) The ability of helical CT to preoperatively stage endometrial carcinoma. AJR 176:603–606
Karla MK, Maher MM, Toth TL, Schmidt B, Westerman BL, Morgan HT, Saini S (2004) Techniques and applications of automatic tube current modulation for CT. Radiology 233:649–657
Murakami T, Kurachi H, Nakamura H, Tsuda K, Miyake A, Tomoda K, Hari S, Kozuka T (1995) Cervical invasion of endometrial carcinoma-evaluation by parasagittal MR imaging. Acta Radiol 36:248–253
Shibutani O, Joja I, Shiraiwa M, Asakawa T, Miyaqi Y, Kudo T, Hiraki Y (1999) Endometrial carcinoma: efficacy of thin-section oblique axial MR images for evaluating cervical invasion. Abdom Imaging 24:520–526
Yamashita Y, Harada M, Sawada T, Takahashi M, Miyazaki K, Okamura H (1993) Normal uterus and FIGO stage I endometrial carcinoma: dynamic gadolinium-enhanced MR imaging. Radiology 186:495–501
International Federation of Gynecology and Obstetrics. Annual report on the results of treatment in gynecologic cancer, vol. 23. Milano, Italy: FIGO 1988
Lien HH, Blomlie V, Trope C, Kaern J, Abeler YM (1991) Cancer of the endometrium: value of MR imaging in determining the depth of invasion into the myometrium. AJR 157:1221–1223
Hricak H, Stern JL, Fisher MR, Shapeero LG, Winkler ML, Lacey CG (1987) Endometrial carcinoma. Staging by MR imaging. Radiology 162:297–305
Sironi S, Taccagni G, Garancini P, Belloni C, DelMaschio A (1992) Myometrial invasion by endometrial carcinoma: assessment by MR imaging. AJR 158:565–569
Yamashita Y, Mizutani H, Torashima M, Takahashi M, Miyazaki K, Okamura H, Ushijima H, Ohtake H, Tokunaga T (1993) Assessment of myometrial invasion by endometrial carcinoma: Transvaginal sonography vs contrast-enhanced MR imaging. AJR 161:595–599
Hirano Y, Kubo K, Hirai Y, Okada S, Yamada K, Sawano S, Yamashita T, Hiramatsu Y (1992) Preliminary experience with gadolinium-enhanced MR imaging for uterine neoplasms. RadioGraphics 12:243–256
Hasumi K, Matsuzawa M, Chen HF, Takahashi M, Sakura M (1982) Computed tomography in the evaluation and treatment of endometrial carcinoma. Cancer 50(5):904–908
Balfe DM, Dyke JV, Lee JKT, Weyman PJ, McClennan BL (1983) Computed tomography in malignant endometrial neoplasms. J Comput Assist Tomogr 7(4):677–681
Walsh JW, Goplerud DR (1982) Computed tomography of primary, persistent and recurrent endometrial malignancy. AJR 139:1149–1154
Dore R, Moro G, D’Andrea F, La Fianza A, Franchi M, Bolis PF (1987) CT evaluation of myometrial invasion in endometrial carcinoma. J Comput Assist Tomogr 11(2):282–289
Varpula MJ, Klemi PJ (1993) Staging of uterine endometrial carcinoma with ultra-low field (0.02) MRI: a comparative study with CT. J Comput Assist Tomogr 17:641–647
Kim SH, Kim HD, Song YS, Kang SB, Lee HP (1995) Detection of deep myometrial invasion in endometrial carcinoma: comparison of transvaginal ultrasound, CT and MRI. J Comput Assist Tomogr 19:766–772
Prokop M (2000) General principles of MDCT. Eur J Rad 45:S4–S10
Dawson P, Lees WR (2001) Multi-slice technology in computed tomography. Clin Radiol 56:302–309
Kohl G (2005) The evolution and state-of-the-art principles of multislice computed tomography. Proc Am Thorac Soc 2:470–476
Scoutt LM, McCarthy SM, Flynn SD, Lange RC, Long F, Smith RC, Chambers SK, Kohorn E, Schwartz P, Chambers JT (1995) Clinical stage I endometrial carcinoma: pitfalls in preoperative assessment with MR imaging. Radiology 194:567–572
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Tsili, A.C., Tsampoulas, C., Dalkalitsis, N. et al. Local staging of endometrial carcinoma: role of multidetector CT. Eur Radiol 18, 1043–1048 (2008). https://doi.org/10.1007/s00330-007-0839-z
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DOI: https://doi.org/10.1007/s00330-007-0839-z