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Image-guided core-needle biopsy of peripheral lymph nodes allows the diagnosis of lymphomas

  • Oncology
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Abstract

It is commonly admitted that the diagnosis of lymphomas can be assessed by the image-guided needle biopsy (IGNB) of deep lymph nodes. However, when peripheral lymph nodes are present, surgical dissection remains the standard strategy. The aim of this study was to evaluate the diagnostic yield of IGNB of peripheral lymph nodes in patients with suspected lymphomas. The records of 180 multisampling IGNBs of peripheral lymph nodes in 180 patients were reviewed. One hundred and twenty-three IGNBs were observed at first diagnosis and 57 at progression using large-cutting core-biopsy needles ranging between 18 G and 14 G in size. Immunohistochemistry studies were performed in all cases and at least one biopsy was systematically frozen. A diagnosis of lymphoma with sufficient information such that a therapeutic decision could be made was obtained in 146 of the 152 patients with lymphoproliferative disorders (96%). IGNB was equally effective in making the correct diagnosis of lymphoma at the time of original diagnosis than at relapse. The results did not depend on the biopsy site, lymph nodes size, or needle type. We recommend that IGNB may be performed as an initial procedure for the diagnosis of lymphomas either in the presence of peripheral or deep lymph nodes, as it avoids surgery.

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Acknowledgment

We thank Martine Vassel for her valuable technical assistance. We hereby warranty that informed consent was obtained from all patients included in this study.

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Authors and Affiliations

  1. Service de Radiologie, Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France

    Eric de Kerviler, Cédric de Bazelaire, Olivier Mathieu & Jacques Frija

  2. Service d’Onco-Hématologie, Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France

    Nicolas Mounier & Christian Gisselbrecht

  3. Service d’Hématologie Pédiatrique, Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France

    Benoît Brethon

  4. Hôpital de jour d’Hématologie, Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France

    Pauline Brice

  5. Service d’Anatomo-Pathologie, Inserm ERM0220 Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France

    Josette Brière

  6. Service d’Onco-Hématologie, Inserm ERM0220 d’Hématologie, Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France

    Jean-Pierre Marolleau

  7. Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France

    Eric de Kerviler, Cédric de Bazelaire, Nicolas Mounier, Olivier Mathieu, Benoît Brethon, Josette Brière, Jean-Pierre Marolleau, Pauline Brice, Christian Gisselbrecht & Jacques Frija

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  1. Eric de Kerviler
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  2. Cédric de Bazelaire
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  3. Nicolas Mounier
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  4. Olivier Mathieu
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  5. Benoît Brethon
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  6. Josette Brière
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  7. Jean-Pierre Marolleau
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  8. Pauline Brice
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  9. Christian Gisselbrecht
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  10. Jacques Frija
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Corresponding author

Correspondence to Eric de Kerviler.

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de Kerviler, E., de Bazelaire, C., Mounier, N. et al. Image-guided core-needle biopsy of peripheral lymph nodes allows the diagnosis of lymphomas. Eur Radiol 17, 843–849 (2007). https://doi.org/10.1007/s00330-006-0393-0

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  • DOI: https://doi.org/10.1007/s00330-006-0393-0

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