Skip to main content
Log in

Reproducibility of multi-detector spiral computed tomography in detection of sub-segmental acute pulmonary embolism

  • Chest
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

The aim of this study was to evaluate the inter-observer and intra-observer agreement of the diagnosis of sub-segmental acute pulmonary embolism (PE) in an inpatient population explored by 16 slice multi-detector spiral computed tomography (MDCT). Four hundred consecutive inpatients were referred for MDCT for the clinical suspicion of acute PE. One hundred and seventy seven (44.2%) had a known cardio-respiratory disease at the time of examination. Inter-observer and intra-observer agreements for the diagnosis of acute PE and of sub-segmental acute PE were assessed blind and independently by three experienced readers and by kappa statistics. Seventy-five patients were diagnosed as having acute PE findings (19.5%), and clots were located exclusively within sub-segmental arteries in nine patients (12%). When clots were limited to sub-segmental or more distal branches of the pulmonary arteries, kappa values were found to be moderate (0.56) to very good (0.85) for the diagnosis of sub-segmental acute PE, whereas for the diagnosis of acute PE in the whole population, kappa values ranged from 0.84 to 0.97. Intra-observer agreement was found to be perfect (kappa=1). MDCT is a reproducible technique for the diagnosis of sub-segmental acute PE as well as for acute PE. In this inpatient population, sub-segmental acute PE was not a rare event.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Schibany N, Fleischmann D, Thallinger C et al (2001) Equipment availability and diagnostic strategies for suspected pulmonary embolism in Austria. Eur Radiol 11:2287–2294

    Article  PubMed  Google Scholar 

  2. Kauczor HU, Heussel CP, Thelen M (1999) Update on diagnostic strategies of pulmonary embolism. Eur Radiol 9:262–275

    PubMed  Google Scholar 

  3. Remy-Jardin M, Remy J, Wattinne L, Giraud F (1992) Central pulmonary thromboembolism: diagnosis with spiral volumetric CT with the single-breath-hold technique—comparison with pulmonary angiography. Radiology 185:381–387

    PubMed  Google Scholar 

  4. Blachere H, Latrabe V, Montaudon M et al (2000) Pulmonary embolism revealed on helical CT angiography: comparison with ventilation–perfusion radionuclide lung scanning. AJR Am J Roentgenol 174:1041–1047

    PubMed  Google Scholar 

  5. Ghaye B, Szapiro D, Mastora I et al (2001) Peripheral pulmonary arteries: how far in the lung does multi-detector row spiral CT allow analysis? Radiology 219:629–636

    PubMed  Google Scholar 

  6. Remy-Jardin M, Baghaie F, Bonnel F, Masson P, Duhamel A, Remy J (2000) Thoracic helical CT: influence of subsecond scan time and thin collimation on evaluation of peripheral pulmonary arteries. Eur Radiol 10:1297–1303

    Article  PubMed  Google Scholar 

  7. Schoepf UJ, Kessler MA, Rieger CT et al (2001) Multislice CT imaging of pulmonary embolism. Eur Radiol 11:2278–2286

    PubMed  Google Scholar 

  8. Schoepf UJ, Holzknecht N, Helmberger TK et al (2002) Subsegmental pulmonary emboli: improved detection with thin-collimation multi-detector row spiral CT. Radiology 222:483–490

    Google Scholar 

  9. Patel S, Kazerooni EA, Cascade PN (2003) Pulmonary embolism: optimization of small pulmonary artery visualization at multi-detector row CT. Radiology 227:455–460

    PubMed  Google Scholar 

  10. Coche E, Pawlak S, Dechambre S, Maldague B (2003) Peripheral pulmonary arteries: identification at multi-slice spiral CT with 3D reconstruction. Eur Radiol 13:815–822

    PubMed  Google Scholar 

  11. Remy-Jardin M, Remy J, Baghaie F, Fribourg M, Artaud D, Duhamel A (2000) Clinical value of thin collimation in the diagnostic workup of pulmonary embolism. AJR Am J Roentgenol 175:407–411

    PubMed  Google Scholar 

  12. Remy-Jardin M, Remy J, Artaud D, Deschildre F, Duhamel A (1997) Peripheral pulmonary arteries: optimization of the spiral CT acquisition protocol. Radiology 204:157–163

    PubMed  Google Scholar 

  13. Stein PD, Henry JW (1997) Prevalence of acute pulmonary embolism in central and subsegmental pulmonary arteries and relation to probability interpretation of ventilation/perfusion lung scans. Chest 111:1246–1248

    PubMed  Google Scholar 

  14. Qanadli SD, Hajjam ME, Mesurolle B et al (2000) Pulmonary embolism detection: prospective evaluation of dual-section helical CT versus selective pulmonary arteriography in 157 patients. Radiology 217:447–455

    PubMed  Google Scholar 

  15. de Monye W, van Strijen MJ, Huisman MV, Kieft GJ, Pattynama PM (2000) Suspected pulmonary embolism: prevalence and anatomic distribution in 487 consecutive patients. Advances in New Technologies Evaluating the Localisation of Pulmonary Embolism (ANTELOPE) Group. Radiology 215:184–188

    PubMed  Google Scholar 

  16. Revel MP, Petrover D, Hernigou A, Lefort C, Meyer G, Frija G (2005) Diagnosing pulmonary embolism with four-detector row helical CT: prospective evaluation of 216 outpatients and inpatients. Radiology 234:265–273

    PubMed  Google Scholar 

  17. Goodman LR, Lipchik RJ, Kuzo RS, Liu Y, McAuliffe TL, O’Brien DJ (2000) Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram—prospective comparison with scintigraphy. Radiology 215:535–542

    Google Scholar 

  18. Musset D, Parent F, Meyer G et al (2002) Diagnostic strategy for patients with suspected pulmonary embolism: a prospective multicentre outcome study. Lancet 360:1914–1920

    Google Scholar 

  19. van Strijen MJ, de Monye W, Kieft GJ et al (2003) Diagnosis of pulmonary embolism with spiral CT as a second procedure following scintigraphy. Eur Radiol 13:1501–1507

    PubMed  Google Scholar 

  20. Perrier A, Bounameaux H (1998) Ultrasonography of leg veins in patients suspected of having pulmonary embolism. Ann Intern Med 128:243; author reply 244–245

    Google Scholar 

  21. Perrier A, Roy PM, Sanchez O et al (2005) Multidetector-row computed tomography in suspected pulmonary embolism. N Engl J Med 352:1760–1768

    PubMed  Google Scholar 

  22. Oser RF, Zuckerman DA, Gutierrez FR, Brink JA (1996) Anatomic distribution of pulmonary emboli at pulmonary angiography: implications for cross-sectional imaging. Radiology 199:31–35

    PubMed  Google Scholar 

  23. Moser KM (1990) Venous thromboembolism. Am Rev Respir Dis 141:235–249

    PubMed  Google Scholar 

  24. Directive Européenne EUR 16262 (1997) Quality criteria for computed tomography

  25. Boyden E (1955) Segmental anatomy of the lungs. McGraw-Hill, New York

    Google Scholar 

  26. Altmann D (1992) Practical statistics for medical research. Chapman & Hall, London

    Google Scholar 

  27. Drucker EA, Rivitz SM, Shepard JA et al (1998) Acute pulmonary embolism: assessment of helical CT for diagnosis. Radiology 209:235–241

    PubMed  Google Scholar 

  28. Remy-Jardin M, Remy J, Deschildre F et al (1996) Diagnosis of pulmonary embolism with spiral CT: comparison with pulmonary angiography and scintigraphy. Radiology 200:699–706

    PubMed  Google Scholar 

  29. Teigen CL, Maus TP, Sheedy PF II et al (1995) Pulmonary embolism: diagnosis with contrast-enhanced electron-beam CT and comparison with pulmonary angiography. Radiology 194:313–319

    PubMed  Google Scholar 

  30. Chartrand-Lefebvre C, Howarth N, Lucidarme O et al (1999) Contrast-enhanced helical CT for pulmonary embolism detection: inter- and intraobserver agreement among radiologists with variable experience. AJR Am J Roentgenol 172:107–112

    PubMed  Google Scholar 

  31. Ruiz Y, Caballero P, Caniego JL et al (2003) Prospective comparison of helical CT with angiography in pulmonary embolism: global and selective vascular territory analysis. Interobserver agreement. Eur Radiol 13:823–829

    PubMed  Google Scholar 

  32. Diffin DC, Leyendecker JR, Johnson SP, Zucker RJ, Grebe PJ (1998) Effect of anatomic distribution of pulmonary emboli on interobserver agreement in the interpretation of pulmonary angiography. AJR Am J Roentgenol 171:1085–1089

    PubMed  Google Scholar 

  33. Baile EM, King GG, Muller NL et al (2000) Spiral computed tomography is comparable to angiography for the diagnosis of pulmonary embolism. Am J Respir Crit Care Med 161:1010–1015

    PubMed  Google Scholar 

  34. Schoepf UJ, Costello P (2004) Images in cardiovascular medicine. Isolated subsegmental pulmonary embolus diagnosed by multidetector-row computed tomography. Circulation 109:e220–e221

    PubMed  Google Scholar 

  35. Henry JW, Relyea B, Stein PD (1995) Continuing risk of thromboemboli among patients with normal pulmonary angiograms. Chest 107:1375–1378

    PubMed  Google Scholar 

  36. Tetalman MR, Hoffer PB, Heck LL, Kunzmann A, Gottschalk A (1973) Perfusion lung scan in normal volunteers. Radiology 106:593–594

    PubMed  Google Scholar 

  37. Raptopoulos V, Boiselle PM (2001) Multi-detector row spiral CT pulmonary angiography: comparison with single-detector row spiral CT. Radiology 221:606–613

    PubMed  Google Scholar 

  38. Garg K, Welsh CH, Feyerabend AJ et al (1998) Pulmonary embolism: diagnosis with spiral CT and ventilation–perfusion scanning—correlation with pulmonary angiographic results or clinical outcome. Radiology 208:201–208

    PubMed  Google Scholar 

  39. Goodman LR, Curtin JJ, Mewissen MW et al (1995) Detection of pulmonary embolism in patients with unresolved clinical and scintigraphic diagnosis: helical CT versus angiography. AJR Am J Roentgenol 164:1369–1374

    PubMed  Google Scholar 

  40. Coche E, Verschuren F, Keyeux A et al (2003) Diagnosis of acute pulmonary embolism in outpatients: comparison of thin-collimation multi-detector row spiral CT and planar ventilation–perfusion scintigraphy. Radiology 229:757–765

    PubMed  Google Scholar 

  41. Wildberger JE, Mahnken AH, Das M, Kuttner A, Lell M, Gunther RW (2005) CT imaging in acute pulmonary embolism: diagnostic strategies. Eur Radiol 15:919–929

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F. Laurent.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brunot, S., Corneloup, O., Latrabe, V. et al. Reproducibility of multi-detector spiral computed tomography in detection of sub-segmental acute pulmonary embolism. Eur Radiol 15, 2057–2063 (2005). https://doi.org/10.1007/s00330-005-2844-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-005-2844-4

Keywords

Navigation