Abstract
Our objective was to retrospectively evaluate the ability of multidetector-row computed tomography (MDCT) to detect previous myocardial infarctions (MIs) and to correlate necrosis with the status of coronary arteries supplying the infarcted territory. After having clinically evaluated 187 patients referred for ECG-gated MDCT of the coronary arteries, 30 previous MIs were identified in 29 patients (9 recent and 21 chronic). MDCT data were evaluated qualitatively and quantitatively by measuring attenuation values and wall thickness within the infarcted region and normal adjacent myocardium. Each MI was also assigned to the distribution territory of a coronary vessel, and morphological data were combined with MDCT angiographic findings. MDCT was able to detect 25/30 MIs showing an overall sensitivity and specificity of 83 and 91%, respectively. Quantitative analysis revealed a statistically significant difference in attenuation values between normal and infarcted regions (38.9±14 HU vs. 104.0±16 HU). Regional wall thinning was observed in chronic MIs (4.1±2 mm vs. 10.5±3.8 mm), and not in patients with recent event (7.9±1.6 mm vs 9.1±4 mm). In 22/25 cases, MDCT angiographic findings showed the presence of suspicious critical lumen narrowing (n=3), previous coronary stenting (n=14) and surgical revascularization (n=5) in the infarct-related coronary. During a single examination, MDCT might provide comprehensive imaging of MI offering a combined morphological and angiographic assessment.
Similar content being viewed by others
References
Ohnesorge B, Flohr T, Becker C, Kopp AF, Schoepf UJ, Baum U, Knez A, Klingenbeck-Regn K, Reiser MF (2000) Cardiac imaging by means of electrocardiographically gated multisection spiral CT: initial experience. Radiology 217:564–571
Achenbach S, Ulzheimer S, Baum U, Kachelriess M, Ropers D, Giesler T, Bautz W, Daniel WG, Kalender WA, Moshage W (2000) Noninvasive coronary angiography by retrospectively ECG-gated multislice spiral CT. Circulation 102:823–828
Dorgelo J, Willems TP, Geluk CA, Van Ooijen PM, Zijlstra F, Oudkerk M (2005) Multidetector computed tomography-guided treatment strategy in patients with non-ST elevation acute coronary syndromes: a pilot study. Eur Radiol 15(4):708–713
Achenbach S, Giesler T, Ropers D, Ulzheimer S, Derlien H, Schulte C, Wenkel E, Moshage W, Bautz W, Daniel WG, Kalender WA, Baum U (2001) Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography. Circulation 103:2535–2538
Pannu HK, Flohr TG, Corl FM, Fishman EK (2003) Current concepts in multi-detector row CT evaluation of the coronary arteries: principles, techniques, and anatomy. Radiographics 23:S111–S125
Rodenwaldt J (2003) Multislice computed tomography of the coronary arteries. Eur Radiol 13:748–757
Desjardins B, Kazerooni EA (2004) ECG-gated cardiac CT. Am J Roentgenol 182(4):993–1010
Hamoir XL, Flohr T, Hamoir V, Labaki L, Tricquet JY, Duhamel A, Kirsch J (2005) Coronary arteries: assessment of image quality and optimal reconstruction window in retrospective ECG-gated multislice CT at 375-ms gantry rotation time. Eur Radiol 15(2):296–304
Lu B, Mao SS, Zhuang N, Bakhsheshi H, Yamamoto H, Takasu J, Liu SC, Budoff MJ (2001) Coronary artery motion during thecardiac cycle and optimal ECG triggering for coronary artery imaging. Invest Radiol 36:250–256
Boxt LM, Lipton MJ, Kwong RY, Rybicki F, Clouse ME (2003) Computed tomography for assessment of cardiac chambers, valves, myocardium and pericardium. Cardiol Clin 21(4):561–585
Ohnesorge BM, Becker CR, Flohr TG, Reiser MF (2002) Multi-slice CT in cardiac imaging. Springer, Berlin Heidelberg New York
Doherty PW, Lipton MJ, Berninger WH, Skioldebrand CG, Carlsson E, Redington RW (1981) Detection and quantitation of myocardial infarction in vivo using transmission computed tomography. Circulation 63:597–606
Lipton MJ, Higgins CB (1980) Evaluation of ischemic heart disease by computerized transmission tomography. Radiol Clin North Am 18:557–576
Hilfiker PR, Weishaupt D, Marincek B (2001) Multislice spiral computed tomography of subacute myocardial infarction. Circulation 28:104(9):1083
Paul JF, Dambrin G, Caussin C, Lancelin B, Angel C (2003) Sixteen-slice computed tomography after acute myocardial infarction from perfusion defect to the culprit lesion. Circulation 2003:108:373–374
Nikolaou K, Knez A, Sagmeister S, Wintersperger BJ, Boekstegers P, Steinbeck G, Reiser MF, Becker CR (2004) Assessment of myocardial infarctions using multidetector-row computed tomography. J Comput Assist Tomogr 28(2):286–292
Alpert JS, Thygesen K, Antman E, Bassand JP (2000–2001) Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36(3):959–969. Erratum in: J Am Coll Cardiol 37(3):973
Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation;105(4):539–542
Gosalia A, Haramati LB, Sheth MP, Spindola-Franco H (2004) CT detection of acute myocardial infarction. Am J Roentgenol 182(6):1563–1566
Hoffmann U, Millea R, Enzweiler C, Ferencik M, Gulick S, Titus J, Achenbach S, Kwait D, Sosnovik D, Brady TJ (2004) Acute myocardial infarction: contrast-enhanced multi-detector row CT in a porcine model. Radiology 231(3):697–701
Boersma E, Mercado N, Poldermans D, Gardien M, Vos J, Simoons ML (2003) Acute myocardial infarction. Lancet 361(9360):847–858
Koyama Y, Mochizuki T, Higaki J (2004) Computed tomography assessment of myocardial perfusion, viability, and function. J Magn Reson Imaging 19(6):800–815
White RD (2004) MR and CT assessment for ischemic cardiac disease. J Magn Reson Imaging 19:659–675
Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, Gross M, Dietz R, Friedrich MG (2004) Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 109(20):2411–2416
Baer FM, Smolarz K, Jungehulsing M, Beckwilm J, Theissen P, Sechtem U, Schicha H, Hilger HH (1992) Chronic myocardial infarction: assessment of morphology, function, and perfusion by gradient echo magnetic resonance imaging and 99 mTc-methoxyisobutyl-isonitrile SPECT. Am Heart J 123:636–645
Masuda Y, Yoshida H, Morooka N, Watanabe S, Inagaki Y (1984) The usefulness of X-ray computed tomography for the diagnosis of myocardial infarction. Circulation 70:217–225
Wisenberg G, Prato FS, Carroll SE, Turner KL, Marshall (1988) Serial nuclear magnetic resonance imaging of acute myocardial infarction with and without reperfusion. Am Heart J 115:510–518
Georgiou D, Bleiweis M, Brundage BH (1992) Conventional and ultrafast computed tomography in the detection of viable versus infarcted myocardium. Am J Card Imaging 6:228–236
Schmermund A, Gerber T, Behrenbeck T, Reed JE, Sheedy PF, Christian TF, Rumberger JA (1998) Measurement of myocardial infarct size by electron beam computed tomography: a comparison with 99 mTc sestamibi. Invest Radiol 33:313–321
Giesler T, Baum U, Ropers D, Ulzheimer S, Wenkel E, Mennicke M, Bautz W, Kalender WA, Daniel WG, Achenbach S (2002) Noninvasive visualization of coronary arteries using contrast-enhanced multidetector CT: influence of heart rate on image quality and stenosis detection. Am J Roentgenol 179:911–916
Schoepf UJ, Becker CR, Ohnesorge BM, Yucel EK (2004) CT of coronary artery disease. Radiology 232(1):18–37
Hong C, Chrysant GS, Woodard PK, Bae KT (2004) Coronary artery stent patency assessed with in-stent contrast enhancement measured at multi-detector row CT angiography: initial experience. Radiology 233(1):286–291
Marano R, Storto ML, Maddestra N, Bonomo L (2004) Non-invasive assessment of coronary artery bypass graft with retrospectively ECG-gated four-row multi-detector spiral computed tomography. Eur Radiol 14(8):1353–1362
Kuijpers D, Janssen CH, van Dijkman PR, Oudkerk M (2004) Dobutamine stress MRI. Part I. Safety and feasibility of dobutamine cardiovascular magnetic resonance in patients suspected of myocardial ischemia. Eur Radiol 14(11):1823–1828
Kuijpers D, van Dijkman PR, Janssen CH, Vliegenthart R, Zijlstra F, Oudkerk M (2004) Dobutamine stress MRI. Part II. Safety and feasibility of dobutamine cardiovascular magnetic resonance in patients suspected of myocardial ischemia. Eur Radiol 14(11):2046–2052
Kuettner A, Kopp AF, Schroeder S, Rieger T, Brunn J, Meisner C, Heuschmid M, Trabold T, Burgstahler C, Martensen J, Schoebel W, Selbmann HK, Claussen CD (2004) Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with angiographically proven coronary artery disease. J Am Coll Cardiol 43(5):831–839
Achenbach S, Giesler T, Ropers D, Ulzheimer S, Anders K, Wenkel E, Pohle K, Kachelriess M, Derlien H, Kalender WA, Daniel WG, Bautz W, Baum U (2003) Comparison of image quality in contrast-enhanced coronary-artery visualization by electron beam tomography and retrospectively electrocardiogram-gated multislice spiral computed tomography. Invest Radiol 38(2):119–128
Jung B, Mahnken AH, Stargardt A, Simon J, Flohr TG, Schaller S, Koos R, Gunther RW, Wildberger JE (2003) Individually weight-adapted examination protocol in retrospectively ECG-gated MSCT of the heart. Eur Radiol 13(12):2560–2566
Jakobs TF, Becker CR, Ohnesorge B, Flohr T, Suess C, Schoepf UJ, Reiser MF (2002) Multislice helical CT of the heart with retrospective ECG gating: reduction of radiation exposure by ECG-controlled tube current modulation. Eur Radiol 12(5):1081–1086
Wintersperger BJ, Nikolaou K, Jakobs TF, Reiser MF, Becker CR (2003) Cardiac multidetector-row computed tomography: initial experience using 16 detector-row systems. Crit Rev Comput Tomogr 44(1):27–45
Nikolaou K, Sanz J, Poon M, Wintersperger BJ, Ohnesorge B, Rius T, Fayad ZA, Reiser MF, Becker CR (2005) Assessment of myocardial perfusion and viability from routine contrast-enhanced 16-detector-row computed tomography of the heart: preliminary results. Eur Radiol 15(5):864–871
Cademartiri F, Mollet N, van der Lugt A, Nieman K, Pattynama PM, de Feyter PJ, Krestin GP (2004) Non-invasive 16-row multislice CT coronary angiography : usefulness of saline chaser. Eur Radiol 14(2):178–183
Flohr T, Stierstorfer K, Raupach R, Ulzheimer S, Bruder H (2004) Performance evaluation of a 64-slice CT system with z-flying focal spot. Rofo 176(12):1803–1810
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Francone, M., Carbone, I., Danti, M. et al. ECG-gated multi-detector row spiral CT in the assessment of myocardial infarction: correlation with non-invasive angiographic findings. Eur Radiol 16, 15–24 (2006). https://doi.org/10.1007/s00330-005-2800-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-005-2800-3