Skip to main content

Advertisement

Log in

Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia

  • Chest
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

The purpose of this study was to evaluate retrospectively the differential CT features of bronchioloalveolar carcinoma (BAC) mimicking pneumonia and infectious pneumonia at the lung periphery. CT images were reviewed in 47 patients with focal areas of parenchymal opacification at the lung periphery. We evaluated the presence of ground-glass attenuation, marginal conspicuity of the lesion, CT angiogram sign, air-bronchogram sign, a bubble-like low-attenuation area within the lesion, presence of pleural thickening and retraction associated with the lesion, presence of pleural effusion and extra-pleural fatty hypertrophy, presence of bronchial wall thickening proximal to the lesion, and air-trapping in the normal lung near the lesion. BAC (n=18) depicted the presence of a bubble-like low-attenuation area within the lesion, whereas infectious pneumonia (n=29) represented the pleural thickening associated with the lesion and bronchial wall thickening proximal to the lesion (P<0.05). The other CT findings showed no significant differences (P>0.05). The focal areas of the parenchymal opacification on the CT images may suggest infectious pneumonia rather than BAC when they show bronchial wall thickening proximal to the lesion and pleural thickening associated with the lesion, whereas BAC is characterized as the presence of a bubble-like low attenuation area within the tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Gaeta M, Blandino A, Pergolizzi S, Mazziotti S, Caruso R, Barone M, Cascinu S (2003) Patterns of recurrence of bronchioloalveolar cell carcinoma after surgical resection: a radiological, histological, and immunohistochemical study. Lung Cancer 42:319–326. DOI 10.1016/S0169-5002(03)00362-3

    Google Scholar 

  2. Barsky SH, Cameron R, Osann KE, Tomita D, Holmes EC (1994) Rising incidence of bronchioloalveolar lung carcinoma and its unique clinicopathologic features. Cancer 73:1163–1170

    Article  PubMed  CAS  Google Scholar 

  3. Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y (2001) The new World Health Organization classification of lung tumours. Eur Respir J 18:1059–1068. DOI 10.1183/09031936.01.00275301

    Google Scholar 

  4. Liebow AA (1960) Bronchiolo-alveolar carcinoma. Adv Intern Med 10:329-358

    PubMed  CAS  Google Scholar 

  5. Kuhn C (1972) Fine structure of bronchiolo-alveolar cell carcinoma. Cancer 30:1107–1118

    Article  PubMed  CAS  Google Scholar 

  6. Hill CA (1984) Bronchioloalveolar carcinoma: a review. Radiology 150:15-20

    PubMed  CAS  Google Scholar 

  7. Sider L (1990) Radiographic manifestations of primary bronchogenic carcinoma. Radiol Clin North Am 28:583–597

    PubMed  CAS  Google Scholar 

  8. Epstein DM (1990) Bronchioloalveolar carcinoma. Semin Roentgenol 25:105–111

    Article  PubMed  CAS  Google Scholar 

  9. Adler B, Padley S, Miller RR, Muller NL (1992) High-resolution CT of bronchioloalveolar carcinoma. AJR Am J Roentgenol 159:275–277

    PubMed  CAS  Google Scholar 

  10. Manning JT Jr, Spjut HJ, Tschen JA (1984) Bronchioloalveolar carcinoma: The significance of two histopathologic types. Cancer 54:525–534

    Article  PubMed  Google Scholar 

  11. Weisbrod GL, Towers MJ, Chamberlain DW, Herman SJ, Matzinger FR (1992) Thin-walled cystic lesions in bronchioalveolar carcinoma. Radiology 185:401–405

    PubMed  CAS  Google Scholar 

  12. Weisbrod GL, Chamberlain D, Herman SJ (1995) Cystic change (pseudocavitation) associated with bronchioloalveolar carcinoma: a report of four patients. J Thorac Imaging 10:106–111

    Article  PubMed  CAS  Google Scholar 

  13. Jang HJ, Lee KS, Kwon OJ, Rhee CH, Shim YM, Han J (1996) Bronchioloalveolar carcinoma: focal area of ground-glass attenuation at thin-section CT as an early sign. Radiology 199:485–488

    PubMed  CAS  Google Scholar 

  14. Kobayashi T, Satoh K, Sasaki M, Mitani M, Takahashi K, Ohkawa M, Tanabe M (1997) Bronchioloalveolar carcinoma with widespread ground-glass shadow on CT in two cases. J Comput Assist Tomogr 21:133–135. DOI 10.1097/00004728-199701000-00026

    Google Scholar 

  15. Kuhlman JE, Fishman EK, Kuhajda FP, Meziane MM, Khouri NF, Zerhouni EA, Siegelman SS (1998) Solitary bronchioloalveolar carcinoma: CT criteria. Radiology 167:379–382

    Google Scholar 

  16. Gaeta M, Caruso R, Blandino A, Bartiromo G, Scribano E, Pandolfo I (1999) Radiolucencies and cavitation in bronchioloalveolar carcinoma: CT-pathologic correlation. Eur Radiol 9:55–59. DOI 10.1007/s003300050627r

    Google Scholar 

  17. Bonomo L, Storto ML, Ciccotosto C, Polverosi R, Merlino B, Bellelli M, Guidotti A (1998) Bronchioloalveolar carcinoma of the lung. Eur Radiol 8:996–1001. DOI 10.1007/s003300050504

    Google Scholar 

  18. Zwirewich CV, Vedal S, Miller RR, Muller NL (1991) Solitary pulmonary nodule: high-resolution CT and radiologic-pathologic correlation. Radiology 179:469–476

    PubMed  CAS  Google Scholar 

  19. Wong JS, Weisbrod GL, Chamberlain D, Herman SJ (1994) Bronchioloalveolar carcinoma and the air bronchogram sign: a new pathologic explanation. J Thorac Imaging 9:141–144

    Article  PubMed  CAS  Google Scholar 

  20. Heitzmann J, Binder PS, Kassar BS, Nordan LT (1993) The correction of high myopia using the excimer laser. Arch Ophthalmol 111:1627–1634

    PubMed  CAS  Google Scholar 

  21. Im JG, Han MC, Yu EJ, Han JK, Park JM, Kim CW, Seo JW, Yoon Y, Lee JD, Lee KS (1990) Lobar bronchioloalveolar carcinoma: "angiogram sign" on CT scans. Radiology 176:749–753

    PubMed  CAS  Google Scholar 

  22. Miyake H, Matsumoto A, Terada A, Yoshida S, Takaki H, Mori H (1995) Mucin-producing tumor of the lung: CT findings. J Thorac Imaging 10:96–98

    Article  PubMed  CAS  Google Scholar 

  23. Murayama S, Onitsuka H, Murakami J, Torii Y, Masuda K, Nishihara K (1993) "CT angiogram sign" in obstructive pneumonitis and pneumonia. J Comput Assist Tomogr 17:609–612

    Article  PubMed  CAS  Google Scholar 

  24. Hammar SP (1994) The pathology of benign and malignant pleural disease. Chest Surg Clin N Am 4:405–430

    PubMed  CAS  Google Scholar 

  25. Butnor KJ, Cooper K (2005) Visceral pleural invasion in lung cancer: recognizing histologic parameters that impact staging and prognosis. Adv Anat Pathol 12:1-6. DOI 10.1097/01.pap.0000151266.26814.02

    Google Scholar 

  26. Bunker ML, Raab SS, Landreneau RJ, Silverman JF (1999) The diagnosis and significance of visceral pleural invasion in lung carcinoma. Histologic predictors and the role of elastic stains. Am J Clin Pathol 112:777–783

    PubMed  CAS  Google Scholar 

  27. Shimizu K, Yoshida J, Nagai K, Nishimura M, Yokose T, Ishii G, Nishiwaki Y (2004) Visceral pleural invasion classification in non-small cell lung cancer: a proposal on the basis of outcome assessment. J Thorac Cardiovasc Surg 127:1574–1578. DOI 10.1016/j.jtcvs.2003.11.017

    Google Scholar 

  28. Sung YM, Lee KS, Kim BT, Han J, Lee EJ (2005) Lobar mucinous bronchioloalveolar carcinoma of the lung showing negative FDG uptake on integrated PET/CT. Eur Radiol 15:2075–2078. DOI 10.1007/s00330-004-2604-x

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tae Hoon Kim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, T.H., Kim, S.J., Ryu, Y.H. et al. Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia. Eur Radiol 16, 1763–1768 (2006). https://doi.org/10.1007/s00330-005-0101-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-005-0101-5

Keywords

Navigation