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Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children

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Abstract

Our objective was to compare fast spin-echo (FSE) short inversion time inversion recovery (STIR) whole-body MR imaging with standard procedures in staging children with lymphoma. Eight children (age range, 2–16 years) underwent multi-station FSE STIR whole-body MR at initial staging (n=5) or for restaging following completion of therapy (n=5). Whole-body MR and conventional staging procedures, including CT (n=10), gallium-67 scintigraphy (n=9), bone scintigraphy (n=3) and bone marrow biopsy (n=7) were retrospectively compared for detection of sites involved by lymphoma and for the assigned stage. FSE STIR whole-body MR detected more sites of possible lymphomatous involvement at initial staging (87/88) and at restaging (5/5) than did conventional imaging (74/88, 3/5). MR was more sensitive than conventional imaging in detecting bone marrow involvement at initial staging. Following treatment, however, residual and therapy-induced bone marrow signal abnormalities could not be differentiated from lymphomatous involvement. Detection of nodal and visceral involvement correlated well. Our results suggest that FSE STIR whole-body MR imaging is a sensitive technique for evaluating lymphomatous involvement of bone marrow as well as non-marrow sites. Larger prospective trials are needed to determine if FSE STIR whole-body MR can replace standard radiographic procedures for initial staging and contribute in the follow-up of lymphoma in children.

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Authors and Affiliations

  1. Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8

    Christian J. Kellenberger, Stephen F. Miller, Mustafa Khan, David L. Gilday & Paul S. Babyn

  2. Department of Paediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8

    Sheila Weitzman

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  1. Christian J. Kellenberger
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  2. Stephen F. Miller
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  3. Mustafa Khan
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  4. David L. Gilday
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  5. Sheila Weitzman
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  6. Paul S. Babyn
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Correspondence to Paul S. Babyn.

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Kellenberger, C.J., Miller, S.F., Khan, M. et al. Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children. Eur Radiol 14, 1829–1841 (2004). https://doi.org/10.1007/s00330-004-2432-z

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  • DOI: https://doi.org/10.1007/s00330-004-2432-z

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