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Assessment of coronary artery stent patency by electron-beam CT

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Abstract

Following coronary angioplasty and stent implantation, restenosis remains common and its outcome difficult to predict. We set out to determine the diagnostic accuracy of electron-beam computed tomography (EBCT) for the non-invasive detection of stent obstruction. In a prospective, blinded investigation, we included 152 coronary artery segments in 117 patients treated with a stent implant. All segments were evaluated by a dynamic EBCT study that depicted contrast bolus passage distal to the stent and a CT angiographic study of the entire coronary arteries. It was found that delayed contrast enhancement in the distal segment correlated with angiographic stent obstruction (Spearman’s rank correlation, P=0.008), while all other indicators of stent occlusion did not correlate with angiographic diagnosis. However, direct comparison of patients with obstruction of less vs. more than 75% of luminal diameter did not yield any statistically significant differences of distal enhancement delay, and for the detection of >90% occlusion, the sensitivity was 72% at a specificity of 60%. Although delayed contrast enhancement distal to the stent upon EBCT did correlate with angiographical obstruction, the correlation did not suffice to appear clinically satisfactory.

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Authors and Affiliations

  1. Department of Radiology, Charité, Campus Virchow-Klinikum, Humboldt-University, Augustenburger Platz 1, 13353, Berlin, Germany

    Friedrich D. Knollmann & Roland Felix

  2. Department of Cardiology, Jüdisches Krankenhaus, Berlin, Germany

    Jörg Möller, Axel Gebert & Christian Bethge

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  1. Friedrich D. Knollmann
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  2. Jörg Möller
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  3. Axel Gebert
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  4. Christian Bethge
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Correspondence to Friedrich D. Knollmann.

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Knollmann, F.D., Möller, J., Gebert, A. et al. Assessment of coronary artery stent patency by electron-beam CT. Eur Radiol 14, 1341–1347 (2004). https://doi.org/10.1007/s00330-004-2337-x

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  • DOI: https://doi.org/10.1007/s00330-004-2337-x

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