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Radio-frequency thermal ablation with hypertonic saline solution injection of the lung: ex vivo and in vivo feasibility studies

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Abstract

The aim of this study was to assess the effects of simultaneous instillation of NaCl solutions during radio-frequency ablation (RFA) on the dimension of the ablated lesion in ex vivo bovine lung tissue and in vivo rabbit lung tissue. The RFA was induced in ex vivo bovine lung tissue which was inflated with room air and in vivo rabbit lung tissue by a 500-kHz RF generator and a 17-G cooled-tip electrode. In in vivo experiments, RFA was performed using CT guidance. The RF energy was applied for 5 min with or without instillation of 0.9 or 36% NaCl solutions. The changes in tissue impedance, current, power output, and temperature of the electrode tip were automatically measured. The maximum diameter of all thermal lesions was measured perpendicular to the electrode axis by two observers. In an ex vivo study, the mean lesion diameters using 36 and 0.9% NaCl solutions were larger than those of the control group: 51±8, 34±6, and 5±2 mm (p<0. 05). In in vivo rabbit lung tissue, the mean lesion diameter with NaCl solution (15.3±3.1 mm) was larger than that of the lesion without NaCl solution (8.5±1.4 mm; p<0.05). With instillation of NaCl solutions, a marked decrease of tissue impedance (>100 Ω) and corresponding increase of current flow occurred in both ex vivo and in vivo studies. This experimental study demonstrates that RF ablation with simultaneous NaCl solution infusion of the lung is more effective in achieving coagulation necrosis than conventional RFA procedure.

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Fig. 1a–e.
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Fig. 3a, b.

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References

  1. Goldberg SN, Gazelle GS, Mueller PR (2000) Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR 174:323–331

    Article  CAS  Google Scholar 

  2. Dupuy DE, Goldberg SN (2001) Image-guided radiofrequency tumor ablation: challenges and opportunities, part II. J Vasc Interv Radiol 12:1135–1148

    Article  CAS  Google Scholar 

  3. Lee JM, Kim SW, Chung GH, Lee SY, Han YM, Kim CS (in press) Open radiofrequency thermal ablation of renal VX2 tumors in a rabbit model using a cooled-tip electrode: feasibility, safety, and effectiveness. Eur Radiol

  4. Merkel EM, Shonk JR, Zheng L, Duerk JL, Lewin JS (2001) MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2 T. Eur Radiol 11:884–892

    Article  Google Scholar 

  5. Curley SA, Izzo F, Ellis LM, Vauthey JN, Vallone P (2000) Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg 232:381–391

    Article  CAS  Google Scholar 

  6. Buscarini L, Buscarini E, Stasi M di, Vallisa D, Quaretti P, Rocca A (2001) Percutaneous radiofrequency ablation of small hepatocellular carcinoma: long-term results. Eur Radiol 11:914–921

    Article  CAS  Google Scholar 

  7. Solbiati L, Ierace T, Goldberg SN, Sironi S, Livraghi T, Fiocca R, Servadio G, Rizzatto G, Mueller PR, Del Maschio A, Gazelle GS (1997) Percutaneous US-guided radiofrequency tissue ablation of liver metastases: treatment and follow-up in 16 patients. Radiology 202:195–203

    Article  CAS  Google Scholar 

  8. Ginsberg RJ, Vokes EE, Raben A (1997) Cancer of the lung: non-small cell lung cancer. In: Pass HD, Mitchel JB, Johnson DH, Turrisi AT (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott-Raven, Philadelphia, pp 849–857

  9. Fry WA, Phillips JL, Menck HR (1999) Ten-year survey of lung cancer treatment and survival in hospitals in the United States: a national cancer data base report. Cancer 86:1867–1876

    Article  CAS  Google Scholar 

  10. Downey RJ (1999) Surgical management of lung cancer. J Thorac Imaging 14:266–269

    Article  CAS  Google Scholar 

  11. Moore DF Jr, Lee JS (1996) Staging and prognostic factors: non-small cell lung cancer. In: Pass HD, Mitchel JB, Johnson DH, Turrisi AT (eds) Lung cancer: principles and practice. Lippincott-Raven, Philadelphia, pp 481–494

  12. Zagoria RJ, Chen MY, Kavanagh PV, Torti FM (2001) Radiofrequency ablation of lung metastases from renal cell carcinoma. J Urol 166:1827–1828

    Article  CAS  Google Scholar 

  13. Dupuy DE, Zagoria RJ, Akerley W, Mayo-Smith WW, Kavanagh PV, Safran H (2000) Percutaneous radiofrequency ablation of malignancies in the lung. AJR 174:57–59

    Article  CAS  Google Scholar 

  14. Highland AM, Mack P, Breen DJ (in press) Radiofrequency thermal ablation of a metastatic lung nodule. Eur Radiol

  15. Goldberg SN, Gazelle GS, Compton CC, Mueller PR, McLoud TC (1996) Radiofrequency tissue ablation of VX2 tumor nodules in the rabbit lung. Acad Radiol 3:929–935

    Article  CAS  Google Scholar 

  16. Miao Y, Ni Y, Bosmans H, Yu J, Vaninbroukx J, Dymarkowski S, Zhang H, Marchal G (2001) Radiofrequency ablation for eradication of pulmonary tumor in rabbits. J Surg Res 99:265–271

    Article  CAS  Google Scholar 

  17. Livraghi T, Goldberg SN, Monti F, Bizzini A, Lazzaroni S, Meloni F, Pellicano S, Solbiati L, Gazelle GS (1997) Saline-enhanced radiofrequency tissue ablation in the treatment of liver metastases. Radiology 202:205–210

    Article  CAS  Google Scholar 

  18. Boehm T, Malich A, Reichenbach JR, Fleck M, Kaiser WA (2001) Percutaneous radiofrequency (RF) thermal ablation of rabbit tumors embedded in fat: a model for RF ablation of breast tumors. Invest Radiol 36:480–486

    Article  CAS  Google Scholar 

  19. Goldberg SN, Ahmed M, Gazelle GS, Kruskal JB, Huertas JC, Halpern EF, Oliver BS, Lenkinski RE (2001) Radiofrequency thermal ablation with NaCl solution injection: effect of electrical conductivity on tissue heating and coagulation-phantom and porcine liver study. Radiology 219:157–165

    Article  CAS  Google Scholar 

  20. Miao Y, Ni Y, Yu J, Zhang H, Baert A, Marchal G (2001) An ex vivo study on radiofrequency tissue ablation: increased lesion size by using an expandable-wet electrode. Eur Radiol 11:1841–1847

    Article  CAS  Google Scholar 

  21. Dodd GD III, Frank MS, Aribandi M, Chopra S, Chrintapalli KN (2001) Radiofrequency thermal ablation: computer analysis of the size of the thermal injury created by overlapping ablations. AJR 177:777–782

    Article  Google Scholar 

  22. Gazelle GS, Goldberg SN, Solbiati L, Livraghi T (2000) Tumor ablation with radiofrequency energy. Radiology 217:633–646

    Article  CAS  Google Scholar 

  23. Goldberg SN, Kruskal JB, Oliver BS, Clouse ME, Gazelle GS (2000) Percutaneous tumor ablation: increased coagulation by combining radiofrequency ablation and ethanol instillation in a rat breast tumor model. Radiology 217:827–831

    Article  CAS  Google Scholar 

  24. Goldberg SN, Kamel IR, Kruskal JB, Reynolds K, Monsky WL, Stuart KE, Ahmed M, Raptopoulos V (2002) Radiofrequency ablation of hepatic tumors: increased tumor destruction with adjuvant liposomal doxorubicin therapy. AJR 179:93–101

    Article  Google Scholar 

  25. Buscarini L, Buscarini E, Stasi M di, Quaretti P, Zangrandi A (1999) Percutaneous radiofrequency thermal ablation combined with transcatheter arterial embolization in the treatment of large hepatocellular carcinoma. Ultraschall Med 20:47–53

    Article  CAS  Google Scholar 

  26. Rossi S, Garbagnati F, Lencioni R, Allgaier HP, Marchiano A, Fornari F, Quaretti P, Tolla GD, Ambrosi C, Mazzaferro V, Blum HE, Bartolozzi C (2000) Percutaneous radiofrequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply. Radiology 217:119–126

    Article  CAS  Google Scholar 

  27. Boehm T, Malich A, Goldberg SN, Reichenbach JR, Hilger I, Hauff P, Reinhardt M, Fleck M, Kaiser WA (2002) Radiofrequency tumor ablation: internally cooled electrode versus saline-enhanced technique in an aggressive rabbit tumor model. Radiology 222:805–813

    Article  Google Scholar 

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Acknowledgements

The authors thank S.O. Lee for her assistance in animal observation and anesthesia, and for her outstanding support in obtaining the CT images. We also thank B. Hami, Department of Radiology, University Hospital of Cleveland, for her editorial assistance and manuscript preparation.

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  1. Jeong Min Lee

    Present address: Department of Diagnostic Radiology, Seoul National University Hospital, Yongon-Dong, Chongno-Gu, 28,, 110-744, Seoul , Korea

Authors and Affiliations

  1. Department of Diagnostic Radiology, Chonbuk National University Medical School, Chonju, Korea

    Jeong Min Lee, Ji Hyun Youk, Young Kon Kim, Young Min Han, Gyung Ho Chung, Sang Yong Lee & Chong Soo Kim

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Correspondence to Jeong Min Lee.

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Lee, J.M., Youk, J.H., Kim, Y.K. et al. Radio-frequency thermal ablation with hypertonic saline solution injection of the lung: ex vivo and in vivo feasibility studies. Eur Radiol 13, 2540–2547 (2003). https://doi.org/10.1007/s00330-003-1876-x

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  • DOI: https://doi.org/10.1007/s00330-003-1876-x

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