Abstract
The use of intravenous immunoglobulin (IVIg) has been reported as an immunomodulating agent in several autoimmune diseases, including systemic lupus erythematosus (SLE). Herein we report a SLE patient with severe clinical presentation that included pericarditis, pleural effusion, nephrotic range proteinuria, leukopenia, and lymphopenia. The patient received one course of high-dose IVIg (2.8 g/kg body weight), and within a week of post-IVIg therapy, her condition significantly improved. One-month post-IVIg there were decreased proteinuria, elevated leukocytes and lymphocytes count, decrease in antinuclear and anti-dsDNA antibodies, and disappearance of pericarditis and pleuritis. This case demonstrates the efficacy of IVIg in severe SLE with various clinical manifestations.
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Received: 14 January 2000 / Accepted: 20 March 2000
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Meissner, M., Sherer, Y., Levy, Y. et al. Intravenous immunoglobulin therapy in a patient with lupus serositis and nephritis. Rheumatology International 19, 199–201 (2000). https://doi.org/10.1007/s002960000053
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DOI: https://doi.org/10.1007/s002960000053