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Acquired angioedema in juvenile systemic lupus erythematosus: case-based review

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Abstract

An acquired form of angioedema that is clinically similar but scarcer than the hereditary form may be caused, even more rarely, by the presence of an underlying autoimmune disease. We report a previously healthy 16-year-old girl with an acquired angioedema as a rare and initial presentation of systemic lupus erythematosus. The patient had no previous angioedema attack and no family history. She did not have any chronic diseases and did not use any medicine regularly. The patient was diagnosed with systemic lupus erythematosus with the presence of polyarthralgia, angioedema, leucopenia, and positivity of immunologic criteria. Her edema resolved with high-dose methylprednisolone and hydroxychloroquine slowly. In conclusion, new-onset angioedema in adolescent girls should be investigated to evaluate autoimmunity and the possibility of systemic lupus erythematosus. The related literature on acquired angioedema associated with systemic lupus erythematosus is also reviewed.

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Acknowledgements

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Pediatric of Rheumatology, Pamukkale University School of Medicine, Pamukkale, Denizli, Turkey

    Zahide Ekici Tekin, Gülçin Otar Yener & Selçuk Yüksel

Authors
  1. Zahide Ekici Tekin
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  2. Gülçin Otar Yener
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  3. Selçuk Yüksel
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Contributions

The case was diagnosed and followed up by SY. ZET conceived and planned the presented case report. ZET and SY wrote the manuscript with support from GOY. Literature data were provided by SY, ZET, and GOY. The manuscript was edited for proper English language by Papercheck Editing Services (1521793396-e).

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Correspondence to Selçuk Yüksel.

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The authors declare that they have no conflict of interest.

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Written informed consent was obtained from the patient and his parents for publication of this case report and an accompanying image.

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Tekin, Z.E., Yener, G.O. & Yüksel, S. Acquired angioedema in juvenile systemic lupus erythematosus: case-based review. Rheumatol Int 38, 1577–1584 (2018). https://doi.org/10.1007/s00296-018-4088-z

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  • DOI: https://doi.org/10.1007/s00296-018-4088-z

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