Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease. Cytokine-mediated immunity plays an important role in the pathogenesis of SLE. TNF-like ligand 1A (TL1A) belongs to the TNF superfamily of cytokines and has been found to perform significantly in autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease. To date, no study has discussed the expression levels of TL1A in SLE. We found that plasma levels of TL1A were significantly higher in newly diagnosed SLE patients compared with controls. Correlation analysis showed that plasma levels of TL1A were positively associated with SLE disease activity index. These data indicated that TL1A may play a role in SLE and may reflect the disease activity for SLE.
References
Migone TS, Zhang J, Luo X et al (2002) TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 16(3):479–492
Song L, Zhou R, Huang S et al (2013) High intestinal and systemic levels of interleukin-23/T-helper 17 pathway in Chinese patients with inflammatory bowel disease. Mediat Inflamm 2013:425915
Sun X, Zhao J, Liu R et al (2013) Elevated serum and synovial fluid TNF-like ligand 1A (TL1A) is associated with autoantibody production in patients with rheumatoid arthritis. Scand J Rheumatol 42(2):97–101
Konsta M, Bamias G, Tektonidou MG, Christopoulos P, Iliopoulos A, Sfikakis PP (2013) Increased levels of soluble TNF-like cytokine 1A in ankylosing spondylitis. Rheumatology (Oxford) 52(3):448–451
Song L, Qiu F, Fan Y et al (2013) Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus. J Clin Immunol 33(1):111–117
Takedatsu H, Michelsen KS, Wei B et al (2008) TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 135(2):552–567
Shih DQ, Zheng L, Zhang X et al (2014) Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunol 7(6):1492–1503
Wang X, Hu Y, Charpentier T et al (2013) TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol 191(11):5420–5429
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This work was partly supported by Grants from the National Natural Science Foundation of China (81102192, 81172764).
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Xu, WD., Chen, DJ., Li, R. et al. Elevated plasma levels of TL1A in newly diagnosed systemic lupus erythematosus patients. Rheumatol Int 35, 1435–1437 (2015). https://doi.org/10.1007/s00296-015-3277-2
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DOI: https://doi.org/10.1007/s00296-015-3277-2