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Role of integrins and their ligands in osteoarthritic cartilage

  • Review Article - Pathology Review
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Abstract

Osteoarthritis (OA) is a degenerative disease, which is characterized by articular cartilage destruction, and mainly affects the older people. The extracellular matrix (ECM) provides a vital cellular environment, and interactions between the cell and ECM are important in regulating many biological processes, including cell growth, differentiation, and survival. However, the pathogenesis of this disease is not fully elucidated, and it cannot be cured totally. Integrins are one of the major receptors in chondrocytes. A number of studies confirmed that the chondrocytes express several integrins including α5β1, αVβ3, αVβ5, α6β1, α1β1, α2β1, α10β1, and α3β1, and some integrins ligands might act as the OA progression biomarkers. This review focuses on the functional role of integrins and their extracellular ligands in OA progression, especially OA cartilage. Clear understanding of the role of integrins and their ligands in OA cartilage may have impact on future development of successful therapeutic approaches to OA.

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Acknowledgments

This work was supported by the Grants from the National Natural Science Foundation of China (No. 81272034, 81201420, 81472130), the Hunan Provincial Innovation Foundation for Postgraduate (CX2012B086), and the Fundamental Research Funds for the Central Universities of Central South University (2013 zzts081).

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The authors declare that they have no conflict of interest.

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  1. Department of Orthopaedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, China

    Jian Tian, Fang-Jie Zhang & Guang-Hua Lei

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  1. Jian Tian
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  2. Fang-Jie Zhang
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Correspondence to Guang-Hua Lei.

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Tian, J., Zhang, FJ. & Lei, GH. Role of integrins and their ligands in osteoarthritic cartilage. Rheumatol Int 35, 787–798 (2015). https://doi.org/10.1007/s00296-014-3137-5

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