Abstract
E2F1 is a transcriptional activator, which binds to DNA, and regulates the expression of genes involved in the cell cycle progression. Many elegant studies have revealed that E2F1 plays a crucial role in regulating the apoptosis process of DC and T cells. In addition, the pathogenesis of SLE involves marked immune dysfunction, and in particular, the function of immunosuppressive elements of the immune system is impaired, including regulatory T cell function and DC. Thus, therapeutic agents targeting E2F1 might result in important innovative therapies for SLE.
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This work was partly supported by grants from National Natural Science Foundation of China (81102192, 81172764).
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Fang, Xy., Ye, Dq. E2F1: a potential therapeutic target for systematic lupus erythematosus. Rheumatol Int 34, 1175–1176 (2014). https://doi.org/10.1007/s00296-013-2873-2
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DOI: https://doi.org/10.1007/s00296-013-2873-2