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Pulmonary function in ankylosing spondylitis: association with clinical variables

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Abstract

To evaluate the association between pulmonary function and clinical variables in ankylosing spondylitis (AS) and to compare the pulmonary function of patients with AS with that of healthy controls, 61 AS patients and 74 healthy controls were included. In AS, we assessed clinical disease indices (BASDAI, BASFI, BASG), morning stiffness, number of hypersensitive entheses, metrology measures, 6-min walking test, acute phase reactants, radiological presence of “bamboo spine,” and severity of radiological involvement in sacroiliac and vertebral joints. AS and healthy controls had similar age and gender. All the parameters of pulmonary function were significantly diminished in AS than in healthy controls (p < 0.001), with a higher proportion of restrictive pattern (57.4 vs. 5.4 %). In AS, pulmonary function correlated negatively with BASDAI, BASFI, BASG, morning stiffness, number of hypersensitive entheses, occiput-wall distance, and ESR, and positively with 6-min walking test. There was no association between pulmonary function with radiological stage of vertebral joints and sacroiliac joints, “bamboo spine,” disease duration, or chest expansion. A higher frequency of AS patients had a decreased pulmonary function and results of the 6-min walking test. These abnormalities in AS were more related with disease activity than with mobility limitation.

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Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico

    A. J. L. Brambila-Tapia & I. P. Dávalos-Rodríguez

  2. Centro Universitario de Ciencias de la Salud (CUCS), Instituto de Genética Humana, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    A. J. L. Brambila-Tapia & I. P. Dávalos-Rodríguez

  3. Programa Nacional de Post-doctorado del Consejo Nacional de Ciencia y Tecnología (CONACYT), Guadalajara, Jalisco, Mexico

    A. D. Rocha-Muñoz

  4. Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    A. D. Rocha-Muñoz, L. Gonzalez-Lopez, L. De la Cerda-Trujillo, M. L. Diaz-Toscano, E. G. Cardona-Muñoz & J. I. Gamez-Nava

  5. Hospital General Regional No. 110, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico

    L. Gonzalez-Lopez & D. Sanchez-Mosco

  6. Doctorado en Salud Pública, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    L. Gonzalez-Lopez & J. I. Gamez-Nava

  7. Centro Universitario de Ciencias de la Salud (CUCS), Instituto de Investigación en Reumatología y del Sistema Musculoesquelético, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    M. Vázquez-Del-Mercado

  8. Unidad de Investigación en Epidemiología Clínica, Hospital de Especialidades Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico

    M. Salazar-Páramo, L. De la Cerda-Trujillo, M. L. Diaz-Toscano, P. Hernandez-Cuervo, V. Diaz-Rizo & J. I. Gamez-Nava

  9. Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    M. Salazar-Páramo

  10. Centro Universitario de Investigación Biomédica, Universidad de Colima, Colima, Mexico

    V. Diaz-Rizo, D. Sanchez-Mosco & J. C. Vazquez-Jimenez

  11. Salto del Agua 2192, Col. Jardines del Country, CP. 44210, Guadalajara, Jalisco, Mexico

    J. I. Gamez-Nava

Authors
  1. A. J. L. Brambila-Tapia
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  2. A. D. Rocha-Muñoz
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  3. L. Gonzalez-Lopez
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  4. M. Vázquez-Del-Mercado
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  5. M. Salazar-Páramo
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  6. I. P. Dávalos-Rodríguez
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  7. L. De la Cerda-Trujillo
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  8. M. L. Diaz-Toscano
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  9. P. Hernandez-Cuervo
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  10. V. Diaz-Rizo
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  11. D. Sanchez-Mosco
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  12. J. C. Vazquez-Jimenez
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  13. E. G. Cardona-Muñoz
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  14. J. I. Gamez-Nava
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Corresponding author

Correspondence to J. I. Gamez-Nava.

Additional information

A. J. L. Brambila-Tapia and A. D. Rocha-Muñoz equally contributed to this study.

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Brambila-Tapia, A.J.L., Rocha-Muñoz, A.D., Gonzalez-Lopez, L. et al. Pulmonary function in ankylosing spondylitis: association with clinical variables. Rheumatol Int 33, 2351–2358 (2013). https://doi.org/10.1007/s00296-013-2723-2

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  • DOI: https://doi.org/10.1007/s00296-013-2723-2

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