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Baseline anti-citrullinated peptide antibody (ACPA) titers and serum interleukin-6 (IL-6) levels possibly predict progression of bone destruction in early stages of rheumatoid arthritis (ERA)

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Abstract

A prospective study was made to seek for a convenient biomarker to predict progression of bone destruction (PBD) in early stages of rheumatoid arthritis (ERA). All participated patients had definite RA and their radiographic stages were mild less than stage II of the Steinbrocker classification, naïve for treatment of any DMARDs or corticosteroids. After the entry, they were treated according to the 2002 ACR management guideline for RA. The candidate biomarkers (RF-IgM, RF-IgG, CARF, ACPA, CRP, ESR, NTx, MMP-3, IL-6 and osteopontin) were measured at the entry. PBD was assessed radiographically by interval changes in the modified Sharp scores (ΔSHS) for 24 months. The associations between ΔSHS and baseline biomarkers were assessed statistically by multivariate regression analyses. Both the baseline ACPA and IL-6 levels correlated with PBD, suggesting that they could predict PBD in ERA.

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Acknowledgments

This work was supported by a Grant-in-Aid for Research of Immunological Disorders from The Japan National Hospital Organization (NHO) and carried out by the iR-net Study Group of NHO. We thank Drs. Yasuda M. and Fujita M. for recruiting the patients and Mr. Yano T. for helping statistical analyses. We also thank Ms. Kitatobe, Ms. Nakata and Ms. Uesugi for their excellent secretarial works.

Conflict of interest

All authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Clinical Research, National Hospital Organization (NHO) Osaka Minami Medical Center, 2-1 Kidohigashi-machi, Kawachinagano City, Osaka, 586-8521, Japan

    Yukihiko Saeki & Shiro Ohshima

  2. Department of Rheumatology, National Hospital Organization (NHO) Osaka Minami Medical Center, Osaka, Japan

    Yukihiko Saeki, Eriko Kudo-Tanaka, Shiro Ohshima, Masato Matsushita, So-ichiro Tsuji, Yu-ichi Maeda, Maiko Yoshimura & Akane Watanabe

  3. Department of Allergology, National Hospital Organization (NHO) Osaka Minami Medical Center, Osaka, Japan

    Yoshinori Katada & Yoshinori Harada

  4. Department of Rheumatology, NHO Hokkaido Medical Center, Sapporo, Japan

    Kenji Ichikawa

  5. Department of Rheumatology, NHO Beppu Medical Center, Beppu, Japan

    Yasuo Suenaga

  6. Department of Rheumatology, NHO Minami-Okayama Medical Center, Okayama, Japan

    Yusuke Ohta

  7. Department of Rheumatology, NHO Sagamihara Hospital, Sagamihara, Japan

    Shigeto Tohma

Authors
  1. Yukihiko Saeki
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  2. Eriko Kudo-Tanaka
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  3. Shiro Ohshima
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  4. Masato Matsushita
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  5. So-ichiro Tsuji
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  6. Yu-ichi Maeda
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  7. Maiko Yoshimura
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  8. Akane Watanabe
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  9. Yoshinori Katada
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  10. Yoshinori Harada
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  11. Kenji Ichikawa
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  12. Yasuo Suenaga
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  13. Yusuke Ohta
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  14. Shigeto Tohma
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NHO iR-net Study Group

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Correspondence to Yukihiko Saeki.

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Saeki, Y., Kudo-Tanaka, E., Ohshima, S. et al. Baseline anti-citrullinated peptide antibody (ACPA) titers and serum interleukin-6 (IL-6) levels possibly predict progression of bone destruction in early stages of rheumatoid arthritis (ERA). Rheumatol Int 33, 451–456 (2013). https://doi.org/10.1007/s00296-012-2397-1

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  • DOI: https://doi.org/10.1007/s00296-012-2397-1

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